Elevated Growth Hormone Levels and Insulin Resistance in Patients with Cirrhosis of the Liver

Carbohydrate intolerance is frequently seen in patients with hepatic cirrhosis. To study the role of the counter regulatory hormones, glucagon, cortisol and growth hormone in this disease, these hormones were measured in 11 patients with hepatic cirrhosis and six controls during a 4-hour oral glucos...

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Bibliographic Details
Published in:The American journal of the medical sciences 1986-04, Vol.291 (4), p.248-254
Main Authors: Shankar, Talla P., Fredi, Joseph L., Himmelstein, Stevan, Solomon, Solomon S., Duckworth, William C.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Glucose - metabolism
Cirrhosis
Gastroenterology. Liver. Pancreas. Abdomen
Glucagon - blood
Glucose - metabolism
Glucose Intolerance
Glucose Tolerance Test
Growth Hormone - blood
High Growth Hormone
Humans
Hydrocortisone - blood
Insulin - blood
Insulin - metabolism
Insulin Resistance
Liver Cirrhosis - blood
Liver Cirrhosis - metabolism
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Metabolic Clearance Rate
Middle Aged
Other diseases. Semiology
Time Factors
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Summary:Carbohydrate intolerance is frequently seen in patients with hepatic cirrhosis. To study the role of the counter regulatory hormones, glucagon, cortisol and growth hormone in this disease, these hormones were measured in 11 patients with hepatic cirrhosis and six controls during a 4-hour oral glucose tolerance test (OGTT) and in five normal and cirrhotic subjects during steady-state plasma insulin and glucose concentrations (SSPGI) achieved with the euglycemic clamp technique. Fasting plasma glucose was 103±4.3mg/dl in cirrhotics and 88±3.3mg/dl in controls (p
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-198604000-00006