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Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression
The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It...
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| Published in: | Science (American Association for the Advancement of Science) 1986-05, Vol.232 (4752), p.877-880 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c809t-2719af8929608afe1c42e4cd2179a3a0919ded9e5a3fdb94123e15c3205bb2a23 |
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| cites | cdi_FETCH-LOGICAL-c809t-2719af8929608afe1c42e4cd2179a3a0919ded9e5a3fdb94123e15c3205bb2a23 |
| container_end_page | 880 |
| container_issue | 4752 |
| container_start_page | 877 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 232 |
| creator | Greene, Warner C. Leonard, Warren J. Wano, Yuji Svetlik, Penny B. Peffer, Nancy J. Sodroski, Joseph G. Rosen, Craig A. Goh, Wei Chun Haseltine, William A. |
| description | The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection. |
| doi_str_mv | 10.1126/science.3010456 |
| format | article |
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The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3010456</identifier><identifier>PMID: 3010456</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>AIDS/HIV ; B lymphocytes ; Biochemistry ; Biological and medical sciences ; Cancer ; Cell Line ; Cell lines ; Deltaretrovirus - genetics ; Epithelial cells ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genes ; Genes, Viral ; Genetics ; Human T lymphotropic virus 1 ; Human T lymphotropic virus 2 ; Humans ; Interleukin-2 ; Interleukin-2 - biosynthesis ; Interleukin-2 - genetics ; Interleukins ; Leukemia - microbiology ; Medical research ; Messenger RNA ; Microbiology ; Nucleic Acid Hybridization ; Plasmids ; Receptors ; Receptors, Immunologic - genetics ; Receptors, Interleukin-2 ; Retroviruses ; RNA, Messenger - genetics ; T cells ; T lymphocytes ; Viral research ; Virology ; Virus research ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1986-05, Vol.232 (4752), p.877-880</ispartof><rights>Copyright 1986 The American Association for the Advancement of Science</rights><rights>1986 INIST-CNRS</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science May 16, 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c809t-2719af8929608afe1c42e4cd2179a3a0919ded9e5a3fdb94123e15c3205bb2a23</citedby><cites>FETCH-LOGICAL-c809t-2719af8929608afe1c42e4cd2179a3a0919ded9e5a3fdb94123e15c3205bb2a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2884,2885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8787077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3010456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greene, Warner C.</creatorcontrib><creatorcontrib>Leonard, Warren J.</creatorcontrib><creatorcontrib>Wano, Yuji</creatorcontrib><creatorcontrib>Svetlik, Penny B.</creatorcontrib><creatorcontrib>Peffer, Nancy J.</creatorcontrib><creatorcontrib>Sodroski, Joseph G.</creatorcontrib><creatorcontrib>Rosen, Craig A.</creatorcontrib><creatorcontrib>Goh, Wei Chun</creatorcontrib><creatorcontrib>Haseltine, William A.</creatorcontrib><title>Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection.</description><subject>AIDS/HIV</subject><subject>B lymphocytes</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Deltaretrovirus - genetics</subject><subject>Epithelial cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Genes, Viral</subject><subject>Genetics</subject><subject>Human T lymphotropic virus 1</subject><subject>Human T lymphotropic virus 2</subject><subject>Humans</subject><subject>Interleukin-2</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Interleukin-2 - genetics</subject><subject>Interleukins</subject><subject>Leukemia - microbiology</subject><subject>Medical research</subject><subject>Messenger RNA</subject><subject>Microbiology</subject><subject>Nucleic Acid Hybridization</subject><subject>Plasmids</subject><subject>Receptors</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, Interleukin-2</subject><subject>Retroviruses</subject><subject>RNA, Messenger - genetics</subject><subject>T cells</subject><subject>T lymphocytes</subject><subject>Viral research</subject><subject>Virology</subject><subject>Virus research</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqN09-L0zAcAPAiyjlPn31RKCL6cPYuv9M8znHuCsWBzvOxZOm3o6NLZ9LK-d-b0XJ3ymAjhEC-n3wTknyj6DVGlxgTceVNDdbAJUUYMS6eRBOMFE8UQfRpNEGIiiRFkj-PXni_QSjEFD2LzkY-iX4unbY-mZqu_q271sVzsBC3VXyzzG-TLIszW_YGfJzlCYm_gYHdXmlbDjMzaJq-0eO667udA-_r1r6MnlW68fBqHM-jH1-ul7ObJF_Ms9k0T0yKVJcQiZWuUkWUQKmuABtGgJmSYKk01UhhVUKpgGtalSvFMKGAuaEE8dWKaELPow9D3p1rf_Xgu2JbexMOpS20vS-kSCkXLD0KqSBKIcKOQoKx4ILToxAzhmToAb77D27a3tlwLSEZ5YQJLgO6GNBaN1DUtmo7p8063KrTTWuhqsP0lFGiUoSD_nRAh1bCtjYH-Md_eBAd3HVr3XtfZN-_nioXt6fKz_MTZTrPH8uLQ9K0TQNrKMLPmS0e66tBG9d676Aqdq7eavenwKjYV0cxVkcxfvew4u34Ev1qC-W9f4i_H-PaG91UoTZM7e9ZKlOJ5P6t3gxs40MxPOwqlMRI0r_J3Bl6</recordid><startdate>19860516</startdate><enddate>19860516</enddate><creator>Greene, Warner C.</creator><creator>Leonard, Warren J.</creator><creator>Wano, Yuji</creator><creator>Svetlik, Penny B.</creator><creator>Peffer, Nancy J.</creator><creator>Sodroski, Joseph G.</creator><creator>Rosen, Craig A.</creator><creator>Goh, Wei Chun</creator><creator>Haseltine, William A.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19860516</creationdate><title>Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression</title><author>Greene, Warner C. ; Leonard, Warren J. ; Wano, Yuji ; Svetlik, Penny B. ; Peffer, Nancy J. ; Sodroski, Joseph G. ; Rosen, Craig A. ; Goh, Wei Chun ; Haseltine, William A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c809t-2719af8929608afe1c42e4cd2179a3a0919ded9e5a3fdb94123e15c3205bb2a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>AIDS/HIV</topic><topic>B lymphocytes</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Deltaretrovirus - genetics</topic><topic>Epithelial cells</topic><topic>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greene, Warner C.</au><au>Leonard, Warren J.</au><au>Wano, Yuji</au><au>Svetlik, Penny B.</au><au>Peffer, Nancy J.</au><au>Sodroski, Joseph G.</au><au>Rosen, Craig A.</au><au>Goh, Wei Chun</au><au>Haseltine, William A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1986-05-16</date><risdate>1986</risdate><volume>232</volume><issue>4752</issue><spage>877</spage><epage>880</epage><pages>877-880</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3010456</pmid><doi>10.1126/science.3010456</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1986-05, Vol.232 (4752), p.877-880 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76835648 |
| source | American Association for the Advancement of Science |
| subjects | AIDS/HIV B lymphocytes Biochemistry Biological and medical sciences Cancer Cell Line Cell lines Deltaretrovirus - genetics Epithelial cells Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genes, Viral Genetics Human T lymphotropic virus 1 Human T lymphotropic virus 2 Humans Interleukin-2 Interleukin-2 - biosynthesis Interleukin-2 - genetics Interleukins Leukemia - microbiology Medical research Messenger RNA Microbiology Nucleic Acid Hybridization Plasmids Receptors Receptors, Immunologic - genetics Receptors, Interleukin-2 Retroviruses RNA, Messenger - genetics T cells T lymphocytes Viral research Virology Virus research Viruses |
| title | Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression |
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