EFFECTS OF I.A. LIGNOCAINE ON ADRENALINE-INDUCED VASOCONSTRICTION

The effects of i.a. administered lignocaine on the in vivo response of the vascular bed supplied by the lingual, external maxillary and posterior auricular branches of the common carotid artery were studied in the rat. Infusions of lignocaine in concentrations of 10–1000 μg ml−1 administered at the...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1986-06, Vol.58 (6), p.649-652
Main Authors: PATEROMICHELAKIS, S., ROOD, J.P.
Format: Article
Language:English
Subjects:
Animals
Arteries - drug effects
Blood Pressure - drug effects
Carotid Arteries - drug effects
Depression, Chemical
Epinephrine - pharmacology
Head - blood supply
Injections, Intra-Arterial
Lidocaine - pharmacology
Male
Rats
Rats, Inbred Strains
Vascular Resistance - drug effects
Vasoconstriction - drug effects
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Summary:The effects of i.a. administered lignocaine on the in vivo response of the vascular bed supplied by the lingual, external maxillary and posterior auricular branches of the common carotid artery were studied in the rat. Infusions of lignocaine in concentrations of 10–1000 μg ml−1 administered at the rate of 0.05 ml min−1 for 10 min did not affect vascular resistance or arterial pressure in the common carotid artery. However, following such infusions, the increase of vascular resistance caused by bolus doses of adrenaline (20–120 ng in 0.1 ml) was inhibited, indicating lignocaine-adrenaline antagonism. Responses to adrenaline remained significantly depressed 60 min after the termination of a 100-μg ml−1 or higher lignocaine infusion.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/58.6.649