Effects of Extracellular Volume Expansion on Plasma Renin Concentration in Rats with Diabetes Insipidus

The effect of acute and chronic expansion of the extracellular fluid volume on plasma renin concentration (PRC) was studied in normal Long-Evans rats (LE rats) and in rats with hereditary hypothalamic diabetes insipidus (DI rats). Chronic deoxycorticosterone acetate (DOCA) treatment, combined with a...

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Bibliographic Details
Published in:The American journal of the medical sciences 1986-04, Vol.291 (4), p.215-221
Main Authors: Fernández–Repollet, Emma, Opava–Stitzer, Susan, Martínez–Maldonado, Manuel
Format: Article
Language:English
Subjects:
Animals
Antidiuretic Hormone
Biological and medical sciences
Desoxycorticosterone - pharmacology
Diabetes Insipidus
Diabetes Insipidus - blood
Diabetes Insipidus - urine
Endocrinopathies
Extracellular Space - physiology
Female
Hematocrit
Hemodynamics
Hypothalamus. Hypophysis. Epiphysis (diseases)
Male
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Potassium - urine
Rats
Rats, Brattleboro
Renin
Renin - blood
Sodium - urine
Sodium Chloride - pharmacology
Time Factors
Volume Expansion
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Summary:The effect of acute and chronic expansion of the extracellular fluid volume on plasma renin concentration (PRC) was studied in normal Long-Evans rats (LE rats) and in rats with hereditary hypothalamic diabetes insipidus (DI rats). Chronic deoxycorticosterone acetate (DOCA) treatment, combined with a high sodium intake, significantly reduced PRC of both DI and LE rats. PRC of DI rats, however, remained higher than that of LE rats. Acute volume expansion, either alone or with DOCA treatment, also significantly diminished PRC of both DI and LE rats. PRC of untreated and DOCA-treated DI rats again remained significantly higher than that of LE rats after acute volume expansion. These findings suggest that the elevated PRC normally observed in DI rats is not due solely to diminished volume of extracellular fluid. Instead, the absence of ADH per se may directly alter renin secretion or the sensitivity of the granular cell to other stimuli.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-198604000-00002