Circulatory Effects of Atracurium in Patients with Cardiovascular Disease

Atracurium 0.4 mg kg−1 which was sufficient to produce neuromuscular blockade sufficient for intubation, was administered as divided bolus doses to 40 patients with severe cardiovascular disease. Little haemodynamic change occurred. A transient reduction in arterial pressure was noted in one patient...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1986-01, Vol.58 (suppl-1), p.83S-88S
Main Authors: Moyers, J.R., Carter, J.G., Fehr, B.L., Lineberry, C.C., Sokoll, M.D., Shimosato, S.
Format: Article
Language:English
Subjects:
Anesthesia, General
Atracurium
Cardiovascular Diseases - physiopathology
Hemodynamics - drug effects
Humans
Isoquinolines - pharmacology
Neuromuscular Blocking Agents - pharmacology
Time Factors
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Summary:Atracurium 0.4 mg kg−1 which was sufficient to produce neuromuscular blockade sufficient for intubation, was administered as divided bolus doses to 40 patients with severe cardiovascular disease. Little haemodynamic change occurred. A transient reduction in arterial pressure was noted in one patient. Atracurium was found to be safe and effective, and administration in small bolus doses separated by 30 may reduce the likelihood of significant circulatory changes.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/58.suppl_1.83S