23Na-NMR studies of Na + interaction with human red cell membranes from normotensives and hypertensives

Na + interaction with unsealed human red cell ghosts has been studied by 23Na-NMR relaxation rate ( R 1) measurements. Data on a total of nine subjects including seven volunteer normotensives (NBP) and two untreated hypertensives (HBP) are presented. Qualitative treatment of the data gives informati...

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Bibliographic Details
Published in:Biophysical chemistry 1986-03, Vol.23 (3), p.237-244
Main Authors: Ong, Richard L., Cheung, Herbert C.
Format: Article
Language:English
Subjects:
(Na + + K +)-A TPase,. Ouabain effect,- Essential hypertension
23Na-NMR
Adolescent
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Erythrocyte membrane
Erythrocyte Membrane - metabolism
Female
Human
Humans
Hypertension - blood
Kinetics
Longitudinal relaxation
Magnetic Resonance Spectroscopy
Male
Medical sciences
Middle Aged
Normotension
Ouabain - pharmacology
Reference Values
Sodium - blood
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Summary:Na + interaction with unsealed human red cell ghosts has been studied by 23Na-NMR relaxation rate ( R 1) measurements. Data on a total of nine subjects including seven volunteer normotensives (NBP) and two untreated hypertensives (HBP) are presented. Qualitative treatment of the data gives information on the dynamic behavior of Na + undergoing fast exchange between the free and bound states. The excess longitudinal relaxation rate (Δ R) −1 plotted against total [Na +], known as the James-Noggle plot, exhibits different behavior for NBP and HBP ghosts, with a relatively low binding constant of approx. 100 M −1 for HBP ( p
ISSN:0301-4622
1873-4200
DOI:10.1016/0301-4622(86)85009-8