Curve-fitting in pharmacokinetics: a comparison between gamma- and biexponential fits

Seven sets of plasma concentration-time data were fitted to both a conventional biexponential equation and a gamma equation. The values of clearance (CL) and mean residence time (MRT) were calculated from the fitted parameters and compared with the values calculated by the trapezoid rule. Both the b...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1986, Vol.30 (2), p.243-244
Main Authors: SAINSBURY, E. J, ASHLEY, J. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Heart Failure - drug therapy
Humans
Kinetics
Medical sciences
Models, Biological
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Practolol - analogs & derivatives
Practolol - blood
Practolol - therapeutic use
Prenalterol
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Summary:Seven sets of plasma concentration-time data were fitted to both a conventional biexponential equation and a gamma equation. The values of clearance (CL) and mean residence time (MRT) were calculated from the fitted parameters and compared with the values calculated by the trapezoid rule. Both the biexponential and gamma equations provided adequate fits to the data. The values of CL and MRT calculated from the biexponential fits correlated very closely with the values calculated by the trapezoid rule, but there were large discrepancies between the values calculated from the gamma fits and the trapezoid rule. The biexponential model appears to be less sensitive to scatter in the data.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00614312