The activity of BMY 28142 a new broad spectrum β-lactamase stable cephalosporin

The in-vitro activity of BMY 28142, an iminomethoxy, aminothiazolyl cephalosporin containing a methyl pyrrolidinio C-3 was compared with that of cefotaxime, ceftazidime, aztreonam, imipenem and tobramycin against various bacteria. BMY 28142 was the most active agent tested against the Enterobacteria...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1986-04, Vol.17 (4), p.441-452
Main Authors: Neu, Harold C., Chin, Nai-Xun, Jules, Kethy, Labthavikul, Porupen
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Bacteria - enzymology
beta-Lactamases - metabolism
Biological and medical sciences
Cefepime
Cephalosporins - metabolism
Cephalosporins - pharmacology
Gram-Negative Aerobic Bacteria - drug effects
Gram-Negative Anaerobic Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Hydrolysis
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Tobramycin - pharmacology
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Summary:The in-vitro activity of BMY 28142, an iminomethoxy, aminothiazolyl cephalosporin containing a methyl pyrrolidinio C-3 was compared with that of cefotaxime, ceftazidime, aztreonam, imipenem and tobramycin against various bacteria. BMY 28142 was the most active agent tested against the Enterobacteriaceae inhibiting 90% at
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/17.4.441