Glucagon‐stimulated respiration and intracellular Ca2

The effects of extra‐ and intracellular Ca2+ on glucagon‐stimulated respiration were examined in perfused rat liver. Glucagon increased the uptake of O2 to a significantly greater extent in Ca2+ ‐containing perfusate than in Ca2+‐free perfusate. If, however, the livers were perfused first with Ca2+‐...

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Bibliographic Details
Published in:FEBS letters 1986-05, Vol.201 (1), p.133-136
Main Author: Kraus-Friedmann, Naomi
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Biological and medical sciences
Ca2
Calcium - metabolism
Calcium - pharmacology
Exact sciences and technology
Fasting
Fundamental and applied biological sciences. Psychology
Glucagon
Glucagon - pharmacology
Gluconeogenesis
Intracellular Fluid - metabolism
Liver
Liver - drug effects
Liver - metabolism
Liver. Bile. Biliary tracts
Male
Other techniques and industries
Oxygen Consumption - drug effects
Rats
Rats, Inbred Strains
Respiration
Vertebrates: digestive system
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Summary:The effects of extra‐ and intracellular Ca2+ on glucagon‐stimulated respiration were examined in perfused rat liver. Glucagon increased the uptake of O2 to a significantly greater extent in Ca2+ ‐containing perfusate than in Ca2+‐free perfusate. If, however, the livers were perfused first with Ca2+‐containing perfusate for 60 min in order to load the hormone‐sensitive Ca2+ pool(s) and subsequently with Ca2+‐free perfusate, glucagon was able to stimulate O2 uptake to the same extent in Ca2+ ‐free, as in Ca2+‐containing perfusate. These experiments support previous observations of a connection between Ca2+ and the hormonal stimulation of respiration, but indicate a role for intracellular, rather than extracellular, Ca2+ in the process.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(86)80585-3