Synthesis of alpha-D-galactopyranosyl-linked oligosaccharides containing the alpha-Gal-->beta-Gal-->GlcNAc sequence employing methyl-2,3,4,6-tetra-O-(4-methoxybenzyl)-1-thio-beta-D-galactopyranosid e as an efficient glycosyl donor

Synthesis of two trisaccharides and a tetrasaccharide, namely, alpha-Gal-(1-->3)-beta-Gal-(1-->3)-GlcNAc-beta-OBn (6), alpha-Gal-(1-->3)-beta-Gal-(1-->4)-GlcNAc-beta-OBn (9) and alpha-Gal-(1-->3)-beta-Gal-(1-->4)-GlcNAc-beta-(1-->6)-GalNAc- alpha-OBn (19) was accomplished throug...

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Bibliographic Details
Published in:Carbohydrate research 1994-10, Vol.263 (1), p.67-77
Main Authors: Reddy, G V, Jain, R K, Bhatti, B S, Matta, K L
Format: Article
Language:English
Subjects:
Carbohydrate Conformation
Carbohydrate Sequence
Glycosylation
Methylgalactosides - chemistry
Molecular Sequence Data
Molecular Structure
Oligosaccharides - chemical synthesis
Trisaccharides - chemical synthesis
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Summary:Synthesis of two trisaccharides and a tetrasaccharide, namely, alpha-Gal-(1-->3)-beta-Gal-(1-->3)-GlcNAc-beta-OBn (6), alpha-Gal-(1-->3)-beta-Gal-(1-->4)-GlcNAc-beta-OBn (9) and alpha-Gal-(1-->3)-beta-Gal-(1-->4)-GlcNAc-beta-(1-->6)-GalNAc- alpha-OBn (19) was accomplished through development and utilization of a key alpha-galactosyl donor, methyl 2,3,4,6-tetra-O-(4- methoxybenzyl)-1-thio-beta-D-galactopyranoside (1).
ISSN:0008-6215