The effect of additive hyaluronic acid on animal joints with experimentally reduced lubricating ability

A series of in vitro experiments demonstrated a clear effect of additive hyaluronic acid (HA) on animal joints with experimentally reduced lubricating ability. Eleven canine hip joints were utilized and the experimental conditions tested were: (i) intact joints, (ii) after washing the joint surfaces...

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Bibliographic Details
Published in:Journal of biomedical materials research 1994-08, Vol.28 (8), p.865-870
Main Authors: Mabuchi, Kiyoshi, Tsukamoto, Yukio, Obara, Takeo, Yamaguchi, Toshijiro
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dogs
Friction
Hip Joint - drug effects
Hip Joint - physiology
Hyaluronic Acid - pharmacology
Joints - drug effects
Lubrication
Medical sciences
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:A series of in vitro experiments demonstrated a clear effect of additive hyaluronic acid (HA) on animal joints with experimentally reduced lubricating ability. Eleven canine hip joints were utilized and the experimental conditions tested were: (i) intact joints, (ii) after washing the joint surfaces, and (iii) after adding 1% HA to them. The frictional coefficient of every joint increased after washing and subsequently decreased after adding HA. The mean values were 0.007 (SD 0.004) on the intact joints, 0.020 (SD 0.009) after washing, and 0.013 (SD 0.005) after the addition of HA. The differences between the three values of frictional coefficients were shown to be statistically significant (p < 0.01). © 1994 John Wiley & Sons, Inc.
ISSN:0021-9304
1097-4636
DOI:10.1002/jbm.820280805