Surface modification of polymers for medical applications

Most of the conventional materials do not meet the demands required for both their surface and bulk properties when used as biomaterials. An effective approach for developing a clinically applicable biomaterial is to modify the surface of the material which already has excellent biofunctionality and...

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Bibliographic Details
Published in:Biomaterials 1994-08, Vol.15 (10), p.725-736
Main Author: Ikada, Y.
Format: Article
Language:English
Subjects:
Biocompatible Materials
Biological and medical sciences
Carbohydrate Sequence
coupling reactions
Equipment and Supplies
graft polymerization
Humans
Medical sciences
Polymer surface modification
Polymers - chemistry
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Surface Properties
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:Most of the conventional materials do not meet the demands required for both their surface and bulk properties when used as biomaterials. An effective approach for developing a clinically applicable biomaterial is to modify the surface of the material which already has excellent biofunctionality and bulk properties. This review article focuses on the surface modification of polymers by grafting techniques, which have long been known in polymer chemistry but are not yet widely applied to biomaterials. A grafted surface can be produced primarily either by graft polymerization of monomers or covalent coupling reaction of existing polymer molecules onto the substrate polymer surface. The major surface properties that should be modified include two kinds of biocompatibility. One is the surface property that elicits the least foreign-body reactions and the other is the cell- and tissuebonding capability. In addition, physiologically active surfaces with, for instance, selective adsorbability may be required. Attempts to produce these biocompatible or biospecific surfaces by grafting techniques are briefly overviewed in this article. Biomaterials (1994) 15, (10) 725–736
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(94)90025-6