C3 nephritic factor and SLE: report of four cases and review of the literature

We present four patients with C3 nephritic factor associated with partial lipodystrophy and/or mes-angiocapillary glomerulonephritis type II. Each of these patients subsequently developed features of SLE, with an onset between 2 and 24 years after the development of the lipodystrophy or glomerulo ne...

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Bibliographic Details
Published in:QJM : An International Journal of Medicine 1994-10, Vol.87 (10), p.609-615
Main Authors: WALPORT, M.J., DAVIES, K.A., BOTTO, M., NAUGHTON, M.A., ISENBERG, D.A., BIASI, D., POWELL, R.J., CHEUNG, N.T., STRUTHERS, G.R.
Format: Article
Language:English
Subjects:
Adult
Complement C3 Nephritic Factor - metabolism
Female
Glomerulonephritis, Membranoproliferative - complications
Humans
Lipodystrophy - complications
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - immunology
Male
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Summary:We present four patients with C3 nephritic factor associated with partial lipodystrophy and/or mes-angiocapillary glomerulonephritis type II. Each of these patients subsequently developed features of SLE, with an onset between 2 and 24 years after the development of the lipodystrophy or glomerulo nephritis. All four patients had antinuclear antibodies and three of the four had anti-Ro antibodies. These patients bring to six the number of reported cases of this association. Possible explanations for the link between these two conditions are discussed.
ISSN:1460-2725
1460-2393
1460-2393
DOI:10.1093/oxfordjournals.qjmed.a068873