Estimation of 99mTc-Dimercaptosuccinic Acid Renal Uptake Using Single Photon Emission Computed Tomography

Renal function was assessed by measurement of 99mTc-dimercaptosuccinic acid (DMSA) uptake by the kidney based on the transectional tomographic image obtained by single photon emission computed tomography (SPECT) . The renal uptake was expressed as percentage of the total radioactivity detected in th...

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Bibliographic Details
Published in:RADIOISOTOPES 1986/03/15, Vol.35(3), pp.115-121
Main Authors: OHISHI, Yukihiko, MACHIDA, Toyohei, KIDO, Akira, TASHIRO, Kazuo, WADA, Tetsuroh, TORII, Shinichiroh, YOSHIGOE, Fukuo, YAMADA, Hideo, CHIBA, Kazuo, TOYAMA, Hinako
Format: Article
Language:Japanese
Subjects:
Adult
Female
Humans
Kidney - diagnostic imaging
Male
Middle Aged
Radioisotope Renography - methods
Reference Values
renal uptake
renal volume
single photon emission computed tomography
Succimer
Sulfhydryl Compounds
Technetium
Technetium Tc 99m Dimercaptosuccinic Acid
technetium-99m-dimercaptosuccinic acid
Tomography, Emission-Computed
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Summary:Renal function was assessed by measurement of 99mTc-dimercaptosuccinic acid (DMSA) uptake by the kidney based on the transectional tomographic image obtained by single photon emission computed tomography (SPECT) . The renal uptake was expressed as percentage of the total radioactivity detected in the kidney, the volume of which was measured by convolution method, against the amount dosed. Absorption was corrected by GE-STAR method using cut of level of 42%. In order to determine normal range, measurement was made for 40 kidneys of each of 10 male and female volunteers confirmed of having normal kidneys both morphologically and functionally. The average volume of the kidney was 220.4 ml for the right and 239.3 ml for the left for males, and 205.9 ml and 236.5 ml, respectively for females. The renal uptake of radioactivity (at 2 h after injection), was 26.8% for the right and 27.6% for the left for males, with corresponding figures for females being 26.4% and 27.9%, respectively. Distribution range of renal volume and renal uptake was obtained by bivariate analysis with 90% and 95% probability. From these results, our method of renal function determination based on renal uptake of99mTc-DMSA obtained from renal transactional tomogram by SPECT is considered to be accurate and potentially useful for clinical purpose.
ISSN:0033-8303
1884-4111
DOI:10.3769/radioisotopes.35.3_115