Measurements of Human Coronary Vascular Impedance

The aim of this study was to develop a method of measuring human coronary circulation impedance in a clinical setting. The authors measured coronary flow reserve (CFR) in 27 patients with chest pain and normal coronary arteries. A Judkins-style, 8F Doppler-tipped angiographic catheter was positioned...

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Bibliographic Details
Published in:Angiology 1994-12, Vol.45 (12), p.991-996
Main Authors: Chauhan, Anoop, Potter, Charles D., Mullins, Paul A., Wheeldon, Derek R., Petch, Michael C., Schofield, Peter M.
Format: Article
Language:English
Subjects:
Adult
Angina Pectoris - physiopathology
Biological and medical sciences
Blood Flow Velocity - physiology
Cardiovascular system
Coronary Angiography
Coronary Circulation - physiology
Echocardiography
Electric Impedance
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Linear Models
Male
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Predictive Value of Tests
Reference Values
Vascular Resistance - physiology
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Summary:The aim of this study was to develop a method of measuring human coronary circulation impedance in a clinical setting. The authors measured coronary flow reserve (CFR) in 27 patients with chest pain and normal coronary arteries. A Judkins-style, 8F Doppler-tipped angiographic catheter was positioned in the left coronary ostium. Resting coronary flow velocity (RFV) and response to a hyperemic 12 mg intracoronary dose of papaverine (PFV) were measured. The signals were recorded by a recorder connected to a micro processor with analogue-to-digital converter and a maths coprocessor. Using this the authors could obtain values for impedance at RFV (IR) and at PFV (IP). The CFR was defined as the ratio: PFV/RFV An impedance index (II) was obtained as the ratio of coronary vascular impedance at peak hyperemia to the impedance at rest. The CFR was 3.2 ±1.2 and the II was 0.33 ±0.11. There was a strong inverse correlation between the CFR and the II (r = -0.9). The authors conclude that this new approach may allow a further insight into the coronary pathophysiology and may become useful in clinical cardiology, eg, in the assess ment of heart transplant and Syndrome X patients.
ISSN:0003-3197
1940-1574
DOI:10.1177/000331979404501201