Effects of NC-1300-O-3 on Gastric Mucus Secretion and Prostaglandin Release in Rats

We investigated the effect of NC-1300-O-3 on gastric mucus secretion and prostaglandin release into the gastric lumen in rats. NC-1300-O-3 following single or repeated administration for up to 4 weeks significantly increased the hexose content in the gastric lumen at 10 to 100 mg/kg, p.o. Omeprazole...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1994, Vol.65(4), pp.319-326
Main Authors: Matsukura, Hitoshi, Masuda, Makoto, Uchida, Aoi, Kamishiro, Toshiro
Format: Article
Language:English
Subjects:
Animals
Anti-Ulcer Agents - pharmacology
Benzimidazoles - pharmacology
Biological and medical sciences
Cimetidine - pharmacology
Digestive system
Dinoprostone - biosynthesis
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Gastric mucus secretion
Hexosamines - metabolism
Hexoses - metabolism
Indomethacin - pharmacology
Male
Medical sciences
Mucus - metabolism
NC-1300-O-3
Omeprazole - pharmacology
Pharmacology. Drug treatments
Prostaglandin
Prostaglandins - metabolism
Rats
Rats, Sprague-Dawley
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Summary:We investigated the effect of NC-1300-O-3 on gastric mucus secretion and prostaglandin release into the gastric lumen in rats. NC-1300-O-3 following single or repeated administration for up to 4 weeks significantly increased the hexose content in the gastric lumen at 10 to 100 mg/kg, p.o. Omeprazole and cimetidine at doses that strongly inhibited gastric acid secretion had no effect on the hexose content following single or repeated administration for 8 days. When administered repeatedly for 8 days, NC-1300-O-3, omeprazole and cimetidine significantly decreased the hexosamine content in gastric surface mucosa, but significantly increased gastric mucus secretion was observed at the same time only with NC-1300-O-3, indicating that this agent has a profile of action on gastric mucus metabolism different from those of omeprazole and cimetidine. NC-1300-O-3 at 10 and 30 mg/kg, p.o. and omeprazole at 30 mg/kg, p.o. increased the release of prostaglandins into the gastric lumen, and this was markedly inhibited by pretreat ment with indomethacin, suggesting that these agents may enhance prostaglandin biosynthesis in the gastric mucosa. From these results, it seems that the enhancement of NC-1300-O-3 on gastric mucus secretion and prostaglandin biosynthesis in the gastric mucosa contribute to the antiulcer effect of NC-1300-O-3.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.65.319