Reperfusion after cerebral ischemia: influence of duration of ischemia

The influence of the duration of ischemia on the pattern of cerebral blood flow in recirculation was studied in anesthetised rats. Severe incomplete cerebral ischemia (mean ischemic flow = 5.8 +/- 0.4 ml/100 g/min) was produced by four-vessel occlusion and recirculation permitted after 15, 30 or 60...

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Published in:Stroke (1970) 1986-05, Vol.17 (3), p.460-466
Main Authors: TODD, N. V, PICOZZI, P, CROCKARD, H. A, RUSSELL, R. R
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Flow Velocity
Brain Ischemia - physiopathology
Cerebral Cortex - blood supply
Cerebrovascular Circulation
Hyperemia - physiopathology
Male
Medical sciences
Nervous system involvement in other diseases. Miscellaneous
Neurology
Perfusion
Rats
Rats, Inbred Strains
Time Factors
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container_issue 3
container_start_page 460
container_title Stroke (1970)
container_volume 17
creator TODD, N. V
PICOZZI, P
CROCKARD, H. A
RUSSELL, R. R
description The influence of the duration of ischemia on the pattern of cerebral blood flow in recirculation was studied in anesthetised rats. Severe incomplete cerebral ischemia (mean ischemic flow = 5.8 +/- 0.4 ml/100 g/min) was produced by four-vessel occlusion and recirculation permitted after 15, 30 or 60 minutes ischemia. All three groups showed an immediate hyperemia followed by hypoperfusion. Hyperemia was maximal following 15 minutes ischemia and least pronounced following 60 minutes ischemia (p = 0.0249). Hypoperfusion started most quickly following 15 minutes ischemia and was delayed following 60 minutes ischemia (p less than 0.001). In established hypoperfusion there was no difference in flow between the three groups. The possible mechanisms of these changes in flow are discussed.
doi_str_mv 10.1161/01.str.17.3.460
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source Alma/SFX Local Collection
subjects Animals
Biological and medical sciences
Blood Flow Velocity
Brain Ischemia - physiopathology
Cerebral Cortex - blood supply
Cerebrovascular Circulation
Hyperemia - physiopathology
Male
Medical sciences
Nervous system involvement in other diseases. Miscellaneous
Neurology
Perfusion
Rats
Rats, Inbred Strains
Time Factors
title Reperfusion after cerebral ischemia: influence of duration of ischemia
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