Platelet Membrane Microparticles in Blood Bank Fresh Frozen Plasma and Cryoprecipitate

Cryoprecipitate has been demonstrated to correct the bleeding abnormality of patients with some congenital (storage pool disease) and acquired (uremia) platelet abnormalities, but the reason for this effect is unknown. We found significant platelet contamination in plasma harvested to prepare fresh...

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Bibliographic Details
Published in:Blood 1986-07, Vol.68 (1), p.307-309
Main Authors: George, James N., Pickett, Elaine B., Heinz, Robert
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Platelets - ultrastructure
Blood Preservation
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Cell Membrane - ultrastructure
Drug Contamination
Factor VIII - therapeutic use
Fibrinogen - therapeutic use
Freezing
Humans
Medical sciences
Plasma
Platelet Count
Space life sciences
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:Cryoprecipitate has been demonstrated to correct the bleeding abnormality of patients with some congenital (storage pool disease) and acquired (uremia) platelet abnormalities, but the reason for this effect is unknown. We found significant platelet contamination in plasma harvested to prepare fresh frozen plasma and cryoprecipi- tate. The platelet membrane microparticles produced by freezing and thawing of the plasma were highly concentrated in cryoprecipitate and may contribute to its therapeutic effect. © 1986 by Grune & Stratton, Inc.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V68.1.307.307