Response Of Human Polymorphonuclear Leukocytes And Monocytes To Trichosporon Beigelii: Host Defense Against An Emerging Opportunistic Pathogen

To further understand human host defenses against Trichosporon beigelii, functional responses were investigated of polymorphonuclear leukocytes (PMNL) and elutriated human monocytes (EHM) to this opportunistic fungal pathogen. There was significantly less PMNL phagocytosis (P < .001) and killing...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-12, Vol.170 (6), p.1557-1565
Main Authors: Lyman, Caron A., Garrett, Kelsey F., Pizzo, Philip A., Walsh, Thomas J.
Format: Article
Language:English
Subjects:
Antigens
Antigens, Fungal - analysis
Bacteriology
Biological and medical sciences
Blood
Candida albicans
Candida albicans - immunology
Cross Reactions
Cytokines
Cytokines - pharmacology
Fundamental and applied biological sciences. Psychology
Humans
Infections
Macrophage Activation
Macrophages
Major Articles
Microbiology
Monocytes
Monocytes - immunology
Monocytes - microbiology
Neutrophils
Neutrophils - immunology
Neutrophils - metabolism
Neutrophils - microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Phagocytosis
Superoxides
Superoxides - metabolism
Trichosporon
Trichosporon - immunology
Trichosporon beigelii
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Summary:To further understand human host defenses against Trichosporon beigelii, functional responses were investigated of polymorphonuclear leukocytes (PMNL) and elutriated human monocytes (EHM) to this opportunistic fungal pathogen. There was significantly less PMNL phagocytosis (P < .001) and killing (P < .001) of T. beigelii isolates than of Candida albicans. However, levels of superoxide anions generated by PMNL in response to T. beigelii and C. albicans were comparable. Pretreatment of PMNL with granulocyte colony-stimulating factor or interferon-v (IFN-')I) did not significantly enhance fungicidal activity. Killing of T. beigelii by EHM also was significantly impaired compared with killing of C. albicans (P < .001). However, pretreatment of EHM with macrophage colony-stimulating factor, granulocyte-macrophage colony- stimulating factor, or IFN-ã all resulted in enhanced fungicidal activity. Thus, phagocytosis and killing of T. beigelii by PMNL and EHM are significantly less efficient than that of C. albicans. However, monocytes may be more important in the control of Trichosporon species than previously shown.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/170.6.1557