Characteristics Of Antibiotic-Resistant Escherichia Coli O157:H7 In Washington State, 1984–1991

The resistance of Escherichia coli O157:H7 to amoxicillin/clavulanic acid, ampicillin, ceftazidime, ceftriaxone, cefuroxime, cephalothin, chloramphenicol, ciprofloxacin, gentamicin, streptomycin, sulfisoxazole, tetracycline, ticarcillin, tobramycin, and trimethoprim-sulfamethoxazole was examined, an...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-12, Vol.170 (6), p.1606-1609
Main Authors: Kim, Harold H., Samadpour, Mansour, Grimm, Linda, Clausen, Carla R., Besser, Thomas E., Baylor, Michael, Kobayashi, John M., Neill, Marguerite A., Schoenknecht, Fritz D., Tarr, Phillip I.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotic resistance
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobials
Bacterial Toxins - genetics
Biological and medical sciences
Colitis
Concise Communications
DNA, Bacterial - analysis
Drug Resistance, Microbial
Escherichia coli
Escherichia coli - classification
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli Infections - microbiology
Feces - microbiology
Genes, Bacterial - genetics
Genotype
Humans
Infections
Labor standards
Medical sciences
Microbial Sensitivity Tests
Pathogens
Pharmacology. Drug treatments
Plasmids
Polymorphism, Restriction Fragment Length
Public health
Shiga Toxin 1
Shiga Toxin 2
Streptomycin - pharmacology
Sulfisoxazole - pharmacology
Tetracycline - pharmacology
Washington
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Summary:The resistance of Escherichia coli O157:H7 to amoxicillin/clavulanic acid, ampicillin, ceftazidime, ceftriaxone, cefuroxime, cephalothin, chloramphenicol, ciprofloxacin, gentamicin, streptomycin, sulfisoxazole, tetracycline, ticarcillin, tobramycin, and trimethoprim-sulfamethoxazole was examined, and resistant strains were characterized. All 56 isolates collected between 1984 and 1987 were susceptible to all antibiotics tested; 13 (7.4%) of 176 strains isolated between 1989 and 1991 were resistant to streptomycin, sulfisoxazole, and tetracycline. A-restriction fragment length polymorphism analysis suggested that the 13 resistant strains belonged to nine different clones. The emerging resistance of E. coli O157:H7 to antibiotics could portend an increased prevalence of this pathogen in food animals that receive antibiotics. Antimicrobial resistance of E. coli O157:H7 could be useful as a rapid epidemiologic marker and as a way to select this pathogen from suspected vehicles of transmission, but this resistance could also complicate therapeutic trials with sulfa-containing antibiotics.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/170.6.1606