Cardiovascular and sympathetic responses to ouabain injected into the hypothalamus in rats

To investigate the effects of sodium-potassium activated adenosine triphosphatase inhibition on central cardiovascular regulation a microinjection of ouabain was given into the hypothalamus of urethane anaesthetised rats. Doses of 0.01-1.0 μ per rat injected into the posterior hypothalamus produced...

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Bibliographic Details
Published in:Cardiovascular research 1986-04, Vol.20 (4), p.294-298
Main Authors: IYODA, ISAO, TAKAHASHI, HAKUO, LEE, LI-CHIK, OKAJIMA, HIROSHI, INOUE, ATSUSHI, SASAKI, SUSUMU, TAKEDA, KAZUO, YOSHIMURA, MANABU, IJICHI, HAMAO
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Animals
Biological and medical sciences
blood pressure
Blood Pressure - drug effects
Cardiotonic agents
Cardiovascular system
central nervous system
digitalis glycoside
Dose-Response Relationship, Drug
Heart Rate - drug effects
Hemodynamics - drug effects
Hypothalamus - drug effects
Male
Medical sciences
microinjection
Ouabain - pharmacology
Pharmacology. Drug treatments
posterior hypothalamus
Rats
Rats, Inbred Strains
sympathetic nerve activity
Sympathetic Nervous System - drug effects
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Summary:To investigate the effects of sodium-potassium activated adenosine triphosphatase inhibition on central cardiovascular regulation a microinjection of ouabain was given into the hypothalamus of urethane anaesthetised rats. Doses of 0.01-1.0 μ per rat injected into the posterior hypothalamus produced a rise in blood pressure within 1 min, the maximum rise occurring 15-20 min later in a dose dependent manner. Both heart rate and abdominal sympathetic nerve activity increased with the rise in blood pressure. Ouabain injected into either the anterior preoptic hypothalamus or the ventromedial hypothalamus produced no notable cardiovascular responses. These results suggest that an endogenous digitalis like substance produced in the hypothalamus as a result of sodium loading may participate in central cardiovascular regulation by increasing sympathetic outflow in the discrete area of the brain, as does ouabain.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/20.4.294