Replication of human cytomegalovirus in a rhabdomyosarcoma cell line depends on the state of differentiation of the cells

The replication of human cytomegalovirus (HCMV) was investigated in a new human rhabdomyosarcoma cell line (KFR) with morphological and biochemical characteristics of fetal striated muscle precursors (rhabdomyoblasts). KFR cells exhibited the unique property for spontaneous morphological transformat...

Full description

Saved in:
Bibliographic Details
Published in:Archives of virology 1994-01, Vol.138 (3-4), p.391-401
Main Authors: CINATL, J. JR, CINATL, J, RADSAK, K, RABENAU, H, WEBER, B, NOVAK, M, BENDA, R, KORNHUBER, B, DOERR, H. W
Format: Article
Language:English
Subjects:
Antigens, Viral - biosynthesis
Base Sequence
Biological and medical sciences
Cell Differentiation
Cytomegalovirus - immunology
Cytomegalovirus - physiology
Fundamental and applied biological sciences. Psychology
Humans
Immediate-Early Proteins - biosynthesis
Microbiology
Molecular Sequence Data
Muscle, Skeletal - cytology
Muscle, Skeletal - virology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Rhabdomyosarcoma - pathology
Tumor Cells, Cultured
Viral Proteins - biosynthesis
Virology
Virus Replication
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The replication of human cytomegalovirus (HCMV) was investigated in a new human rhabdomyosarcoma cell line (KFR) with morphological and biochemical characteristics of fetal striated muscle precursors (rhabdomyoblasts). KFR cells exhibited the unique property for spontaneous morphological transformation from a poorly-differentiated state into well-differentiated (myotube-like) rhabdomyoblasts. The poorly-differentiated rhabdomyoblasts promoted both complete viral gene expression and the production of infectious virus. In contrast, in well-differentiated rhabdomyoblasts HCMV infection was abortive. The results showed that replication of HCMV in this human rhabdomyosarcoma cell line depended on the state of cellular differentiation.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01379143