Empirical antimicrobial therapy with Timentin plus amikacin in febrile granulocytopenic cancer patients

Timentin (ticarcillin plus clavulanic acid) plus amikacin was administered as an empirical regimen to 52 febrile granulocytopenic patients with cancer and appeared as effective as the other commonly recommended combinations of antimicrobial agents. A favourable response was observed in 61% of episod...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1986-05, Vol.17 Suppl C, p.195-201
Main Authors: Meunier, F, Snoeck, R, Lagast, H, Woussen, F, Klastersky, J
Format: Article
Language:English
Subjects:
Adult
Aged
Agranulocytosis - complications
Amikacin - administration & dosage
Amikacin - pharmacology
Amikacin - therapeutic use
Bacteria - drug effects
Bacteria - isolation & purification
Bacterial Infections - drug therapy
Bacterial Infections - etiology
Bacterial Infections - microbiology
Clavulanic Acids - administration & dosage
Clavulanic Acids - pharmacology
Clavulanic Acids - therapeutic use
Drug Combinations - administration & dosage
Drug Combinations - pharmacology
Drug Combinations - therapeutic use
Drug Evaluation
Drug Therapy, Combination
Female
Fever - drug therapy
Fever - etiology
Humans
Kanamycin - analogs & derivatives
Male
Middle Aged
Neoplasms - complications
Penicillin Resistance
Penicillins - therapeutic use
Sepsis - drug therapy
Sepsis - etiology
Ticarcillin - administration & dosage
Ticarcillin - pharmacology
Ticarcillin - therapeutic use
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Summary:Timentin (ticarcillin plus clavulanic acid) plus amikacin was administered as an empirical regimen to 52 febrile granulocytopenic patients with cancer and appeared as effective as the other commonly recommended combinations of antimicrobial agents. A favourable response was observed in 61% of episodes with bacteraemia and in 83% of the episodes without bacteraemia. However, the efficacy in Gram-positive bacteraemia was suboptimal and the emergence of superinfections caused by Gram-positive cocci may represent a clinical challenge.
ISSN:0305-7453
DOI:10.1093/jac/17.suppl_C.195