Androgen turnover during marathon running

The purpose of the study was to investigate the effect of prolonged physical stress on peripheral androgen turnover. Venous blood samples were taken from 18 athletes 24 h before finishing a competitive marathon run and directly after running the race. Serum cortisol, testosterone (T), dehydroepiandr...

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Bibliographic Details
Published in:Medicine and science in sports and exercise 1994-10, Vol.26 (10), p.1274-1277
Main Authors: PONJEE, G. A. E, DE ROOY, H. A. M, VADER, H. L
Format: Article
Language:English
Subjects:
Adult
Androgens - blood
Androgens - metabolism
Androstane-3,17-diol - analogs & derivatives
Androstane-3,17-diol - blood
Biological and medical sciences
Cholestenone 5 alpha-Reductase
Dehydroepiandrosterone - analogs & derivatives
Dehydroepiandrosterone - blood
Dehydroepiandrosterone Sulfate
Fundamental and applied biological sciences. Psychology
Hematocrit
Humans
Hydrocortisone - blood
Liver - metabolism
Male
Metabolic Clearance Rate
Oxidoreductases - metabolism
Physical Endurance - physiology
Running - physiology
Sex Hormone-Binding Globulin - analysis
Space life sciences
Testosterone - blood
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:The purpose of the study was to investigate the effect of prolonged physical stress on peripheral androgen turnover. Venous blood samples were taken from 18 athletes 24 h before finishing a competitive marathon run and directly after running the race. Serum cortisol, testosterone (T), dehydroepiandrosteronesulfate (DHEAS), sex hormone binding globulin (SHBG), and 5 alpha-androstane- 3 alpha, 17 beta-diolglucuronide (3 alpha-AdiolG) were determined and corrected for hemoconcentration. Marathon running caused a rise in serum cortisol concentration in all athletes. Furthermore, a significant (P < 0.01) rise in serum T and T-index (index of free T) was observed. The significant (P < 0.01) rise in serum DHEAS concentration, a mainly adrenal cortical androgen, pointed toward a stimulation of the adrenal cortex or a reduced hepatic metabolic clearance rate. Finally, 3 alpha-AdiolG, an androgen metabolite exclusively formed in peripheral tissues, was increased in the sera of all athletes. These results suggest that marathon running leads to increased concentrations of serum adrenal and gonadal androgens. The simultaneously increased 3 alpha-AdiolG levels may be caused by increased androgen turnover in peripheral tissues containing 5 alpha-reductase.
ISSN:0195-9131
1530-0315
DOI:10.1249/00005768-199410000-00015