Yunnanxane and Its Homologous Esters from Cell Cultures of Taxus chinensis var. mairei

From cell cultures of Taxus chinensis var. mairei, yunnanxane [2 alpha, 5 alpha, 10-beta triacetoxy-14 beta-(2'-methyl-3'-hydroxyl)-butyryloxy-4(20),11-taxadiene, [1], and four new homologous esters, 2 alpha, 5 alpha, 10 beta, 14 beta- tetra-acetoxy-4(20),11-taxadiene [2], 2 alpha, 5 alpha...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1994-09, Vol.57 (9), p.1320-1324
Main Authors: Ma, Wenwen, Stahlhut, Roy W, Adams, Tom L, Park, Gary L, Evans, William A, Blumenthal, Sibylle G, Gomez, George A, Nieder, Matthew H, Hylands, Peter J
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - biosynthesis
Antineoplastic Agents, Phytogenic - chemistry
CELL CULTURE
CELL SUSPENSIONS
Cells, Cultured
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CULTIVO DE CELULAS
CULTURE DE CELLULE
Diterpenes - chemistry
Drugs, Chinese Herbal - chemistry
ESPECTROMETRIA
ESTER
ESTERES
ESTERS
Magnetic Resonance Spectroscopy
MOLECULAR CONFORMATION
molecular structure
Plant Stems - cytology
Plant Stems - metabolism
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
TAXUS
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Summary:From cell cultures of Taxus chinensis var. mairei, yunnanxane [2 alpha, 5 alpha, 10-beta triacetoxy-14 beta-(2'-methyl-3'-hydroxyl)-butyryloxy-4(20),11-taxadiene, [1], and four new homologous esters, 2 alpha, 5 alpha, 10 beta, 14 beta- tetra-acetoxy-4(20),11-taxadiene [2], 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-propionyloxy-4(20),11-taxadiene [3], 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-isobutyryloxy-4(20),11- taxadiene [4], and 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-(2'-methyl)-butyryloxy-4(20),11- taxadiene [5] have been isolated. Their structures were determined by spectroscopic methods.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50111a027