Decreased Water and Potassium Content in Erythrocytes in Essential Hypertension

The water content in erythrocytes of subjects with borderline or established essential hypertension was measured by using gas-liquid chromatography and was found to be lower than that in normotensive controls (p < 0.01). The water content in erythrocytes of normal controls (n = 14), borderline hy...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1986-07, Vol.8 (7), p.618-624
Main Authors: KAWARABAYASHI, TAKAHIKO, KANAYAMA, YOSHIHARU, TAKEUCHI, KAZUHIDE, OKU, HISAO, KOHNO, MASAKAZU, YOSHIMURA, TAKAYOSHI, YASUNARI, KENICHI, TAKEDA, TADANAO, KAGEYAMA, KATSUHIRO, KINOSHITA, YOSHIHIRO
Format: Article
Language:English
Subjects:
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Fluids - analysis
Body Water - analysis
Body Water - metabolism
Cardiology. Vascular system
Chromatography, Gas
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Erythrocytes - analysis
Female
Humans
Hypertension - blood
Intracellular Fluid - analysis
Male
Medical sciences
Middle Aged
Potassium - blood
Potassium - metabolism
Sodium - blood
Sodium - metabolism
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Summary:The water content in erythrocytes of subjects with borderline or established essential hypertension was measured by using gas-liquid chromatography and was found to be lower than that in normotensive controls (p < 0.01). The water content in erythrocytes of normal controls (n = 14), borderline hypertensive subjects (n = 18), and established essential hypertensive subjects (n = 23) was (mean ± SE) 71.0 ± 0.2%, 69.9 ± 0.2%, and 69.3 ± 0.1% (vol/vol), respectively. A definite negative correlation was found between water content of erythrocytes and mean arterial pressure in normotensive and hypertensive subjects (n = 60, r = −0.59, p < 0.001). Although there was no statistically significant between-group difference in the sodium content, the potassium content of erythrocytes from subjects with essential hypertension was significantly lower than that of normotensive controls (0.205 ± 0.003 vs 0.222 ± 0.004 fimoVrng dry red blood cells; p < 0.01). There was no between-group correlation of sodium and water content in erythrocytes, but the potassium content correlated with the water content (n = 46, r = 0.49, p < 0.001).
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.8.7.618