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A new human leukemia cell 8.2 kDa differentiation factor: Isolation and primary structure

A new 8.2 kDa differentiation factor has been purified to homogeneity from the cultural media of human myelogenous HL-60 leukemia cells induced by retinoic acid. cDNA clones encoding this factor were isolated from a cDNA library prepared from HL-60 differentiated cells and their nucleotide sequence...

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Published in:	FEBS letters 1994-12, Vol.356 (2), p.327-329
Main Authors:	Kostanyan, Irina A., Astapova, Mariya V., Starovoytova, Elena V., Dranitsina, Svetlana M., Lipkin, Valery M.
Format:	Article
Language:	English
Subjects:	Amino Acid Sequence Base Sequence Cell Differentiation Cell Line Chromatography, Ion Exchange Cloning, Molecular Differentiation factor DNA, Complementary Electrophoresis, Polyacrylamide Gel HL-60 cell Humans Leukemia, Promyelocytic, Acute Molecular Sequence Data Molecular Weight Neoplasm Proteins - biosynthesis Neoplasm Proteins - chemistry Neoplasm Proteins - isolation & purification Oligonucleotide Probes Retinoic acid Tumor Cells, Cultured
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creator	Kostanyan, Irina A. Astapova, Mariya V. Starovoytova, Elena V. Dranitsina, Svetlana M. Lipkin, Valery M.
description	A new 8.2 kDa differentiation factor has been purified to homogeneity from the cultural media of human myelogenous HL-60 leukemia cells induced by retinoic acid. cDNA clones encoding this factor were isolated from a cDNA library prepared from HL-60 differentiated cells and their nucleotide sequence has been determined. The deduced amino acid sequence of the differentiation factor molecule consists of 54 amino acid residues. The protein is shown to be glycosylated. It was shown by Northern blot experiments that the level of poly(A) + RNA with a length of 450 nucleotides was higher in differentiated cells than in non-differentiated cells.
doi_str_mv	10.1016/0014-5793(94)01306-3
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The deduced amino acid sequence of the differentiation factor molecule consists of 54 amino acid residues. The protein is shown to be glycosylated. 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It was shown by Northern blot experiments that the level of poly(A) + RNA with a length of 450 nucleotides was higher in differentiated cells than in non-differentiated cells.</description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Cell Differentiation</subject><subject>Cell Line</subject><subject>Chromatography, Ion Exchange</subject><subject>Cloning, Molecular</subject><subject>Differentiation factor</subject><subject>DNA, Complementary</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>HL-60 cell</subject><subject>Humans</subject><subject>Leukemia, Promyelocytic, Acute</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - chemistry</subject><subject>Neoplasm Proteins - isolation & purification</subject><subject>Oligonucleotide Probes</subject><subject>Retinoic acid</subject><subject>Tumor Cells, Cultured</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqNkM1O3TAQhS1URG-BN6CSVxVdBDxx7NhdIAHlAhISG1iwsnydsTDkB-wExNuTkCuWpSvLc86cmfkI2QN2AAzkIWNQZKLUfF8XvxlwJjO-QRagSp7xQqpvZPFp-U5-pPTAxr8CvUW2SsWEkmJB7o5pi6_0fmhsS2scHrEJljqsa6oOcvr419IqeI8R2z7YPnQt9db1XfxDL1NXzxXbVvQphsbGN5r6OLh-iLhDNr2tE-6u321yuzy7Ob3Irq7PL0-PrzJX6HFT6TVIVELmGpnnlfZo5WqFTlaQo7O5885L4RSHVelFKQAqKQCZQKu5yPk2-TXnPsXuecDUmyak6QDbYjckU0oNTDL9pRGkKnQOajQWs9HFLqWI3qyPM8DMhN5MXM3E1ejCfKA3fGz7uc4fVg1Wn01r1qO-nPXXUOPbf2Wa5dlJPglTXRcf1WnQ0RyEI9aXgNEkF7B1WIWIrjdVF_696TvnTKWT</recordid><startdate>19941219</startdate><enddate>19941219</enddate><creator>Kostanyan, Irina A.</creator><creator>Astapova, Mariya V.</creator><creator>Starovoytova, Elena V.</creator><creator>Dranitsina, Svetlana M.</creator><creator>Lipkin, Valery M.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19941219</creationdate><title>A new human leukemia cell 8.2 kDa differentiation factor: Isolation and primary structure</title><author>Kostanyan, Irina A. ; 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The deduced amino acid sequence of the differentiation factor molecule consists of 54 amino acid residues. The protein is shown to be glycosylated. It was shown by Northern blot experiments that the level of poly(A) + RNA with a length of 450 nucleotides was higher in differentiated cells than in non-differentiated cells.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>7805865</pmid><doi>10.1016/0014-5793(94)01306-3</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
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source	ScienceDirect Journals
subjects	Amino Acid Sequence Base Sequence Cell Differentiation Cell Line Chromatography, Ion Exchange Cloning, Molecular Differentiation factor DNA, Complementary Electrophoresis, Polyacrylamide Gel HL-60 cell Humans Leukemia, Promyelocytic, Acute Molecular Sequence Data Molecular Weight Neoplasm Proteins - biosynthesis Neoplasm Proteins - chemistry Neoplasm Proteins - isolation & purification Oligonucleotide Probes Retinoic acid Tumor Cells, Cultured
title	A new human leukemia cell 8.2 kDa differentiation factor: Isolation and primary structure
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