Excretion of 3-hydroxy-diflunisal as a monosulphate conjugate—identification using ESI-MS

Electrospray-ionization mass spectrometry was used to identify a novel, highly polar metabolite of diflunisal isolated from Gunn rat urine. Negative ion spectra were obtained of the sulphate conjugate of diflunisal and the new metabolite, which was identified as a sulphate conjugate of 3-hydroxydifl...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1994-09, Vol.12 (9), p.1075-1078
Main Authors: Dickinson, R.G, King, A.R, Kelly, M.A, Kaltashov, I.A, Fenselau, C
Format: Article
Language:English
Subjects:
Analysis
Animals
Biological and medical sciences
Chromatography, High Pressure Liquid
Diflunisal
Diflunisal - analogs & derivatives
Diflunisal - isolation & purification
Diflunisal - metabolism
Diflunisal - urine
electrospray-ionization mass spectrometry (ESI-MS)
General pharmacology
hydroxylation
Mass Spectrometry - methods
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Gunn
Sulfates - metabolism
sulphation
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Summary:Electrospray-ionization mass spectrometry was used to identify a novel, highly polar metabolite of diflunisal isolated from Gunn rat urine. Negative ion spectra were obtained of the sulphate conjugate of diflunisal and the new metabolite, which was identified as a sulphate conjugate of 3-hydroxydiflunisal.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(94)00053-0