Transmissible Lymphoma and Simian Acquired Immunodeficiency Syndrome in Rhesus Monkeys

Four rhesus monkeys (Macaca mulatta) were inoculated with a homogenate of a cutaneous lepromatous leprosy lesion from a mangabey monkey (Cercocebus atys). One died of B-cell lymphoma. and another died of an immunodeficiency syndrome. Cell suspensions prepared from the tumor and spleen of the monkey...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1986-07, Vol.77 (1), p.127-139
Main Authors: Baskin, Gary B., Martin, Louis N., Rangan, S. R. S., Gormus, Bobby J., Corb, Michael Murphey, Wolf, Robert H., Soike, Kenneth F.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - microbiology
Acquired Immunodeficiency Syndrome - transmission
AIDS/HIV
Animal tumors. Experimental tumors
Animals
Antibodies, Monoclonal
Biological and medical sciences
Cell Line
Cells, Cultured
Cercopithecidae - microbiology
Cytopathogenic Effect, Viral
Deltaretrovirus - immunology
DNA Restriction Enzymes
DNA, Viral - analysis
Experimental malignant blood diseases
Female
Herpesvirus 4, Human - genetics
Lymphocytes - classification
Lymphoma - immunology
Lymphoma - pathology
Lymphoma - transmission
Macaca mulatta
Male
Medical sciences
Microscopy, Electron
Retroviridae Infections - transmission
Tumor Virus Infections - transmission
Tumors
Virion - ultrastructure
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Summary:Four rhesus monkeys (Macaca mulatta) were inoculated with a homogenate of a cutaneous lepromatous leprosy lesion from a mangabey monkey (Cercocebus atys). One died of B-cell lymphoma. and another died of an immunodeficiency syndrome. Cell suspensions prepared from the tumor and spleen of the monkey with lymphoma induced lymphoma or an immunodeficiency syndrome when inoculated into additional young rhesus monkeys. The immunodeficiency syndrome was similar to simian acquired immunodeficiency syndrome and consisted of opportunistic infections. lymphoid hyperplasia or atrophy. wasting. and syncytial cell formation. Mitogen responses and percentages of T4- and T8-positive lymphocytes were normal until the animals were moribund. Lymphoblastoid cell lines became established in vitro from tumor cell suspensions. These cells were infected with a herpesvirus related to Epstein-Barr virus. In addition, a retrovirus morphologically similar to human T-cell lymphotrophic virus type III (HTLV-III) and simian T-Iymphotrophic virus type III (STLV-III) was isolated from one of the Iymphoblastoid cell lines (LCL). Type o retroviruses could not be demonstrated in the monkeys in the transmission study; however. a retrovirus similar to that in the LCL was isolated from 4 animals by coculture of peripheral blood lymphocytes with the human cell line H9. These results suggest that this retrovirus, STLV-III/Delta, may be associated with the immunodeficiency syndrome in these macaques and may be of mangabey origin.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/77.1.127