Hamacanthins A and B, New Antifungal Bis Indole Alkaloids from the Deep-Water Marine Sponge, Hamacantha Sp

Hamacanthin A [1] and hamacanthin B [2] are two bioactive dihydropyrazinonediylbis(indole) alkaloids isolated from a new species of deep-water marine sponge, Hamacantha sp. The hamacanthins are growth inhibitors of Candida albicans and Cryptococcus neoformans. Isolation and structure elucidation of...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1994-10, Vol.57 (10), p.1437-1441
Main Authors: Gunasekera, Sarath P, McCarthy, Peter J, Kelly-Borges, Michelle
Format: Article
Language:English
Subjects:
ALCALOIDE
ALCALOIDES
ALKALOIDS
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
ANTIFUNGAL PROPERTIES
Bacillus subtilis - drug effects
CANDIDA ALBICANS
Candida albicans - drug effects
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CRYPTOCOCCUS (CHAMPIGNON)
CRYPTOCOCCUS (FUNGI)
CRYPTOCOCCUS (HONGO)
CRYPTOCOCCUS NEOFORMANS
Cryptococcus neoformans - drug effects
ESPECTROMETRIA
Hamacantha
INDOL
Indole Alkaloids
INDOLES
Indoles - chemistry
Indoles - isolation & purification
Indoles - pharmacology
MADEIRA
MADERE
Magnetic Resonance Spectroscopy
Marine
Microbial Sensitivity Tests
MOLECULAR CONFORMATION
PARAZOA
Porifera - chemistry
PROPIEDADES ANTIMICOSICAS
PROPRIETE ANTIFONGIQUE
Pyrazines - chemistry
Pyrazines - isolation & purification
Pyrazines - pharmacology
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
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Description
Summary:Hamacanthin A [1] and hamacanthin B [2] are two bioactive dihydropyrazinonediylbis(indole) alkaloids isolated from a new species of deep-water marine sponge, Hamacantha sp. The hamacanthins are growth inhibitors of Candida albicans and Cryptococcus neoformans. Isolation and structure elucidation of 1 and 2 by nmr spectroscopy are described.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50112a014