Identification of a putative second T-cell receptor

Framework monoclonal antibodies have identified a population of human lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) α- and β-subunits. Chemical crosslinking experiments reveal that these lymphocytes express novel T3-associated polypeptides, one of which appears to be...

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Bibliographic Details
Published in:Nature (London) 1986-07, Vol.322 (6075), p.145-149
Main Authors: Dialynas, Deno P, Krangel, Michael S, Brenner, Michael B, Strominger, Jack L, Smith, John A, Ip, Stephen, Rosen, Fred, McLean, Joanne, Owen, Frances L, Seidman, J. G
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Antibodies, Monoclonal
Biological and medical sciences
Cell Line
DNA
Electrophoresis
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humanities and Social Sciences
Humans
Immunobiology
Immunologic Deficiency Syndromes - immunology
multidisciplinary
Nucleic Acid Hybridization
Organs and cells involved in the immune response
Receptors, Antigen, T-Cell - analysis
Science
Science (multidisciplinary)
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Summary:Framework monoclonal antibodies have identified a population of human lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) α- and β-subunits. Chemical crosslinking experiments reveal that these lymphocytes express novel T3-associated polypeptides, one of which appears to be the product of the Tγ gene. The other polypeptide may represent a fourth TCR subunit, designated Tδ.
ISSN:0028-0836
1476-4687
DOI:10.1038/322145a0