Antacid and formula effects on gastric acidity in infants with gastroesophageal reflux

A variety of peptic diseases are treated with antacids. Antacid dose requirements for young children have not been extensively evaluated. Moreover, the effects of formula feedings on antacid requirements are also unknown. We have investigated the effects of antacids and formula feedings on gastric a...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1986-07, Vol.78 (1), p.55-57
Main Authors: Sutphen, J L, Dillard, V L, Pipan, M E
Format: Article
Language:English
Subjects:
Aluminum Hydroxide - pharmacology
Antacids - pharmacology
Bottle Feeding
Drug Combinations - pharmacology
Female
Gastric Acid - secretion
Gastroesophageal Reflux - physiopathology
Humans
Hydrogen-Ion Concentration
Infant
Infant Food
Magnesium - pharmacology
Magnesium Hydroxide - pharmacology
Male
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Summary:A variety of peptic diseases are treated with antacids. Antacid dose requirements for young children have not been extensively evaluated. Moreover, the effects of formula feedings on antacid requirements are also unknown. We have investigated the effects of antacids and formula feedings on gastric acidity in infants less than 1 year of age. Small formula feedings of 15 mL/kg per feeding significantly improve antacid buffering of 0.5 mL/kg per dose of standard magnesium-aluminum hydroxide antacids.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.78.1.55