Human Prion Protein cDNA: Molecular Cloning, Chromosomal Mapping, and Biological Implications

A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1986-07, Vol.233 (4761), p.364-367
Main Authors: Liao, Yu-Cheng J., Lebo, Roger V., Clawson, Gary A., Smuckler, Edward A.
Format: Article
Language:English
Subjects:
Alzheimers disease
Amino Acid Sequence
Amino acids
Animals
Base Sequence
Biological and medical sciences
Chromosome Mapping
Chromosomes
Chromosomes, Human, 19-20
Chromosomes, Human, 21-22 and Y
Cloning
Cloning, Molecular
Complementary DNA
Creutzfeldt-Jakob disease
Creutzfeldt-Jakob Syndrome - genetics
Creutzfeldt-Jakob Syndrome - microbiology
Cricetinae
DNA
DNA - analysis
DNA Restriction Enzymes - metabolism
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Genetic research
Genetics
Gin
Hamsters
Humans
Medical disorders
Medical research
Messenger RNA
Molecular and cellular biology
Molecular genetics
Nucleotides
Prions
Prions - genetics
Proteins
Slow virus diseases
Viral Proteins - analysis
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Summary:A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3014653