Invasive Pulmonary Aspergillosis in Nonimmunocompromised, Nonneutropenic Hosts

Invasive pulmonary aspergillosis occurs predominantly in individuals who are neutropenic or who have severe defects in cell-mediated immunity. The isolation of Aspergillus from respiratory secretions of normal hosts usually signifies tracheobronchial colonization, not disease. Recent experience with...

Full description

Saved in:
Bibliographic Details
Published in:Reviews of infectious diseases 1986-05, Vol.8 (3), p.357-363
Main Authors: KARAM, G. K, GRIFFIN, F. M. JR
Format: Article
Language:English
Subjects:
Abscesses
Aged
Aspergillosis
Aspergillosis - blood
Aspergillosis - diagnosis
Aspergillosis - immunology
Aspergillus
Biological and medical sciences
Chest
Human mycoses
Humans
Hyphae
Immunocompetence
Infectious diseases
Invasive pulmonary aspergillosis
Leukocyte Count
Lung diseases
Lung Diseases, Fungal - blood
Lung Diseases, Fungal - diagnosis
Lung Diseases, Fungal - immunology
Lungs
Male
Medical sciences
Middle Aged
Mycoses
Mycoses of the respiratory system
Neutrophils
Review Articles
Secretion
Sputum
Sputum - microbiology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Invasive pulmonary aspergillosis occurs predominantly in individuals who are neutropenic or who have severe defects in cell-mediated immunity. The isolation of Aspergillus from respiratory secretions of normal hosts usually signifies tracheobronchial colonization, not disease. Recent experience with three nonimmunocompromised patients who had invasive pulmonary aspergillosis, each of whom had Aspergillus isolated from respiratory secretions early in his illness, led to a reassessment of the significance of the isolation of Aspergillus from tracheobronchial secretions. Two of 10 nonimmunocompromised, nonleukopenic individuals who had pulmonary infiltrates and whose sputum yielded Aspergillus had invasive pulmonary aspergillosis, whereas two of five individuals who had pulmonary infiltrates and whose bronchial washings grew Aspergillus had invasive disease. These findings indicate that invasive pulmonary aspergillosis should be considered when Aspergillus is isolated from the respiratory secretions of anyone who has pneumonia, regardless of host defense status.
ISSN:0162-0886