Calcium and Sodium Channels in Spontaneously Contracting Vascular Muscle Cells

Electrophysiological recordings of inward currents from whole cells showed that vascular muscle cells have one type of sodium channel and two types of calcium channels. One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It...

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Published in:Science (American Association for the Advancement of Science) 1986-07, Vol.233 (4762), p.475-478
Main Authors: Sturek, Michael, Hermsmeyer, Kent
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological and medical sciences
Blood vessels and receptors
Cadmium
Calcium
Calcium - physiology
Calcium channels
cardiac muscle
Cell lines
Cell membranes
Depolarization
Electric current
Electric potential
Electrophysiology
Fundamental and applied biological sciences. Psychology
Ion Channels - physiology
Medical research
Membrane Potentials
Muscle cells
Muscle Contraction
Muscle, Smooth, Vascular - physiology
Muscular system
Rats
Rats, Inbred WKY
sodium
Sodium - physiology
Sodium channels
Vertebrates: cardiovascular system
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description Electrophysiological recordings of inward currents from whole cells showed that vascular muscle cells have one type of sodium channel and two types of calcium channels. One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It was equally permeable to calcium and barium and was blocked by cadmium, but not by tetrodotoxin. The other type, the sustained calcium channel, was activated by larger depolarizations, but inactivated very little; it was more permeable to barium than calcium. The sustained calcium channel was more sensitive to block by cadmium than the transient channel, but also was not blocked by tetrodotoxin. The sodium channel inactivated 15 times more rapidly than the transient calcium channel and at more negative voltages. This sodium channel, which is unusual because it is only blocked by a very high (60 $\mu $M) tetrodotoxin concentration but not by cadmium, is the first to be characterized in vascular muscle, and together with the two calcium channels, provides a basis for different patterns of excitation in vascular muscles.
doi_str_mv 10.1126/science.2425434
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One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It was equally permeable to calcium and barium and was blocked by cadmium, but not by tetrodotoxin. The other type, the sustained calcium channel, was activated by larger depolarizations, but inactivated very little; it was more permeable to barium than calcium. The sustained calcium channel was more sensitive to block by cadmium than the transient channel, but also was not blocked by tetrodotoxin. The sodium channel inactivated 15 times more rapidly than the transient calcium channel and at more negative voltages. This sodium channel, which is unusual because it is only blocked by a very high (60 $\mu $M) tetrodotoxin concentration but not by cadmium, is the first to be characterized in vascular muscle, and together with the two calcium channels, provides a basis for different patterns of excitation in vascular muscles.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2425434</identifier><identifier>PMID: 2425434</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Animals ; Biochemistry ; Biological and medical sciences ; Blood vessels and receptors ; Cadmium ; Calcium ; Calcium - physiology ; Calcium channels ; cardiac muscle ; Cell lines ; Cell membranes ; Depolarization ; Electric current ; Electric potential ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; Ion Channels - physiology ; Medical research ; Membrane Potentials ; Muscle cells ; Muscle Contraction ; Muscle, Smooth, Vascular - physiology ; Muscular system ; Rats ; Rats, Inbred WKY ; sodium ; Sodium - physiology ; Sodium channels ; Vertebrates: cardiovascular system</subject><ispartof>Science (American Association for the Advancement of Science), 1986-07, Vol.233 (4762), p.475-478</ispartof><rights>Copyright 1986 The American Association for the Advancement of Science</rights><rights>1986 INIST-CNRS</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 25, 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c729t-7b4247a3dcb5787bc779ff45c4b25eb54cb6c548426a7b2323b14417e1100b7c3</citedby><cites>FETCH-LOGICAL-c729t-7b4247a3dcb5787bc779ff45c4b25eb54cb6c548426a7b2323b14417e1100b7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1697819$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1697819$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,2871,2872,27905,27906,58219,58452</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=8768571$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2425434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sturek, Michael</creatorcontrib><creatorcontrib>Hermsmeyer, Kent</creatorcontrib><title>Calcium and Sodium Channels in Spontaneously Contracting Vascular Muscle Cells</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Electrophysiological recordings of inward currents from whole cells showed that vascular muscle cells have one type of sodium channel and two types of calcium channels. One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It was equally permeable to calcium and barium and was blocked by cadmium, but not by tetrodotoxin. The other type, the sustained calcium channel, was activated by larger depolarizations, but inactivated very little; it was more permeable to barium than calcium. The sustained calcium channel was more sensitive to block by cadmium than the transient channel, but also was not blocked by tetrodotoxin. The sodium channel inactivated 15 times more rapidly than the transient calcium channel and at more negative voltages. 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Psychology</subject><subject>Ion Channels - physiology</subject><subject>Medical research</subject><subject>Membrane Potentials</subject><subject>Muscle cells</subject><subject>Muscle Contraction</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>Muscular system</subject><subject>Rats</subject><subject>Rats, Inbred WKY</subject><subject>sodium</subject><subject>Sodium - physiology</subject><subject>Sodium channels</subject><subject>Vertebrates: cardiovascular system</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqN081v0zAUAHALgUYpnLmAFCEEh5HNn7FzHBGUSWU9FHaNHMcJqRyn2InE_nscJdoGqtQqh8R5Pz8_2c8AvEbwAiGcXHrVaKv0BaaYUUKfgAWCKYtTDMlTsICQJLGAnD0HL7zfQRhiKTkDZzNfgJtMGtUMbSRtGW27cvzMfklrtfFRY6PtvrO9tLobvLmLsjBwUvWNraNb6dVgpIu-D14ZHWXaGP8SPKuk8frV_F6Cn1-__Mi-xevN6jq7WseK47SPeUEx5ZKUqmBc8EJxnlYVZYoWmOmCUVUkilFBcSJ5gQkmBaIUcY0QhAVXZAk-THn3rvs9aN_nbeNVqGAqNedJioVI6VFIGIKMJuIoxAhxRAQ7CkOhWCQCBvjuP7jrBmfDtoRkhGGO0Vjf-YRqaXTe2KobN7jWVjtpOqurJvy-ooRTAce1Px3Q4Sl126gD_OM_PIhe_-lrOXifX29vTpWb21Pl59WJUqzWj-X5Iak6Y3St89A52eaxvpy0cp33Tlf53jWtdHc5gvl4KfL5UuRzl4cZb-eTGIpWl_f-If5-joeelqZy0qrG3zPBE8HC4S_Bm4ntfN-5h1WTlAuUkr95BhjO</recordid><startdate>19860725</startdate><enddate>19860725</enddate><creator>Sturek, Michael</creator><creator>Hermsmeyer, Kent</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>M7Z</scope><scope>7X8</scope></search><sort><creationdate>19860725</creationdate><title>Calcium and Sodium Channels in Spontaneously Contracting Vascular Muscle Cells</title><author>Sturek, Michael ; Hermsmeyer, Kent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c729t-7b4247a3dcb5787bc779ff45c4b25eb54cb6c548426a7b2323b14417e1100b7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Blood vessels and receptors</topic><topic>Cadmium</topic><topic>Calcium</topic><topic>Calcium - physiology</topic><topic>Calcium channels</topic><topic>cardiac muscle</topic><topic>Cell lines</topic><topic>Cell membranes</topic><topic>Depolarization</topic><topic>Electric current</topic><topic>Electric potential</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. 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One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It was equally permeable to calcium and barium and was blocked by cadmium, but not by tetrodotoxin. The other type, the sustained calcium channel, was activated by larger depolarizations, but inactivated very little; it was more permeable to barium than calcium. The sustained calcium channel was more sensitive to block by cadmium than the transient channel, but also was not blocked by tetrodotoxin. The sodium channel inactivated 15 times more rapidly than the transient calcium channel and at more negative voltages. This sodium channel, which is unusual because it is only blocked by a very high (60 $\mu $M) tetrodotoxin concentration but not by cadmium, is the first to be characterized in vascular muscle, and together with the two calcium channels, provides a basis for different patterns of excitation in vascular muscles.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>2425434</pmid><doi>10.1126/science.2425434</doi><tpages>4</tpages></addata></record>
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identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1986-07, Vol.233 (4762), p.475-478
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source American Association for the Advancement of Science; JSTOR
subjects Animals
Biochemistry
Biological and medical sciences
Blood vessels and receptors
Cadmium
Calcium
Calcium - physiology
Calcium channels
cardiac muscle
Cell lines
Cell membranes
Depolarization
Electric current
Electric potential
Electrophysiology
Fundamental and applied biological sciences. Psychology
Ion Channels - physiology
Medical research
Membrane Potentials
Muscle cells
Muscle Contraction
Muscle, Smooth, Vascular - physiology
Muscular system
Rats
Rats, Inbred WKY
sodium
Sodium - physiology
Sodium channels
Vertebrates: cardiovascular system
title Calcium and Sodium Channels in Spontaneously Contracting Vascular Muscle Cells
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