In-vitro steroid sensitivity in patients with chronic uraemia and renal transplantation : possible association with HLA phenotypes

We studied in-vitro steroid sensitivity using the test of ADCC in 207 haemodialysed chronic uremic patients, 85 renal transplant patients, and 75 healthy blood donors as normal controls. The association of HLA phenotypes with the in-vitro steroid sensitivity was assessed. The proportion of steroid-s...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1994, Vol.9 (10), p.1474-1476
Main Authors: KOVANECZ, I, CSAJBOK, E, PETRI, I. B
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Chi-Square Distribution
Cyclosporine - pharmacology
HLA Antigens - drug effects
HLA Antigens - genetics
Humans
Immunomodulators
Kidney Failure, Chronic - immunology
Kidney Failure, Chronic - therapy
Kidney Transplantation - immunology
Medical sciences
Odds Ratio
Pharmacology. Drug treatments
Phenotype
Prednisolone - pharmacology
Renal Dialysis
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Description
Summary:We studied in-vitro steroid sensitivity using the test of ADCC in 207 haemodialysed chronic uremic patients, 85 renal transplant patients, and 75 healthy blood donors as normal controls. The association of HLA phenotypes with the in-vitro steroid sensitivity was assessed. The proportion of steroid-sensitive subjects was significantly higher in the normal control group than in the patients. A significant association was observed between HLA B8 carriers and steroid resistance and between HLA DR6 carriers and steroid sensitivity.
ISSN:0931-0509
1460-2385
1460-2385
DOI:10.1093/ndt/9.10.1474