In-vitro steroid sensitivity in patients with chronic uraemia and renal transplantation : possible association with HLA phenotypes

We studied in-vitro steroid sensitivity using the test of ADCC in 207 haemodialysed chronic uremic patients, 85 renal transplant patients, and 75 healthy blood donors as normal controls. The association of HLA phenotypes with the in-vitro steroid sensitivity was assessed. The proportion of steroid-s...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1994, Vol.9 (10), p.1474-1476
Main Authors: KOVANECZ, I, CSAJBOK, E, PETRI, I. B
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Chi-Square Distribution
Cyclosporine - pharmacology
HLA Antigens - drug effects
HLA Antigens - genetics
Humans
Immunomodulators
Kidney Failure, Chronic - immunology
Kidney Failure, Chronic - therapy
Kidney Transplantation - immunology
Medical sciences
Odds Ratio
Pharmacology. Drug treatments
Phenotype
Prednisolone - pharmacology
Renal Dialysis
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container_end_page 1476
container_issue 10
container_start_page 1474
container_title Nephrology, dialysis, transplantation
container_volume 9
creator KOVANECZ, I
CSAJBOK, E
PETRI, I. B
description We studied in-vitro steroid sensitivity using the test of ADCC in 207 haemodialysed chronic uremic patients, 85 renal transplant patients, and 75 healthy blood donors as normal controls. The association of HLA phenotypes with the in-vitro steroid sensitivity was assessed. The proportion of steroid-sensitive subjects was significantly higher in the normal control group than in the patients. A significant association was observed between HLA B8 carriers and steroid resistance and between HLA DR6 carriers and steroid sensitivity.
doi_str_mv 10.1093/ndt/9.10.1474
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1460-2385
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source Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025
subjects Alleles
Biological and medical sciences
Chi-Square Distribution
Cyclosporine - pharmacology
HLA Antigens - drug effects
HLA Antigens - genetics
Humans
Immunomodulators
Kidney Failure, Chronic - immunology
Kidney Failure, Chronic - therapy
Kidney Transplantation - immunology
Medical sciences
Odds Ratio
Pharmacology. Drug treatments
Phenotype
Prednisolone - pharmacology
Renal Dialysis
title In-vitro steroid sensitivity in patients with chronic uraemia and renal transplantation : possible association with HLA phenotypes
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