The Long Term Effects of Percutaneous Transluminal Angioplasty for Treating Patients with Renovascular Hypertension: Case Studies

• Published in: Angiology 1986-07, Vol.37 (7), p.535-542
• Main Authors: Ohta, Hiromichi, Takabatake, Toshikazu, Yamamoto, Yoshiharu, Ishida, Yoh-ichi, Hara, Hiromoto, Ushiogi, Yasuyuki, Nakamura, Saburo, Kawabata, Masahiko, Hashimoto, Naoteru, Sasaki, Tohru, Sato, Shigehiko, Yamada, Yuh-ji, Hattori, Nobu
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Angioplasty, Balloon; Arterial Occlusive Diseases - complications; Arteriosclerosis - complications; Biological and medical sciences; Blood Pressure; Female; Fibromuscular Dysplasia - complications; Humans; Hypertension, Renovascular - etiology; Hypertension, Renovascular - physiopathology; Hypertension, Renovascular - therapy; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Renal Circulation; Renin-Angiotensin System; Urinary system involvement in other diseases. Miscellaneous
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/000331978603700708

Percutaneous transluminal angioplasty was performed on 10 patients with unilateral renovascular hypertension (7 with atheromatous and 3 with fibro muscular stenoses) who were then followed for an average of 42 months (range, 24 to 67 months). Dilatation of the stenosis was initially successful in all patients except one who had severe atheromatous stenosis. Among patients with ather omatous disease, normotension was attained for 40, 25 and 24 months in 3 patients given no antihypertensive medication and for 67 and 55 months in 2 patients given only nicardipine. The remaining one patient had a recurrent stenosis 3 months after angioplasty. All patients with fibromuscular dysplasia have been normotensive without any hypotensive medication for more than 4 years. Plasma renin activity declined within one week after angioplasty and remained unchanged thereafter in all patients except the one case suffering from a recurrent stenosis. Renal blood flow and glomerular filtration rate re mained increased after angioplasty. These results suggest that hypertension can be controlled and renal dysfunction in patients with renal artery stenosis caused by atheroma or fibromuscular dysplasia improved for long periods by percuta neous transluminal angioplasty. The antihypertensive effect obtained by this procedure was more valuable for the patients with fibromuscular dysplasia than in those with atheromatous disease.