Chlorpromazine-sensitized photooxidation of squalene

In connection with chlorpromazine-induced skin photosensitivity, chlorpromazine-sensitized photooxidation of squalene was studied in vitro. When squalene (in ethanolic solution or in an aqueous suspension) was irradiated with UV-A light in the presence of chlorpromazine, the yield of peroxidation pr...

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Bibliographic Details
Published in:Archives of Dermatological Research 1986-05, Vol.278 (3), p.224-227
Main Authors: FUJITA, H, MATSUO, I, OKAZAKI, M, YOSHINO, K, OHKIDO, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chlorpromazine - pharmacology
Humans
In Vitro Techniques
Medical sciences
Models, Biological
Oxidation-Reduction
Oxygen - metabolism
Pharmacology. Drug treatments
Photochemistry
Photosensitivity Disorders - etiology
Photosensitivity Disorders - metabolism
Singlet Oxygen
Skin, nail, hair, dermoskeleton
Squalene - radiation effects
Ultraviolet Rays
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Summary:In connection with chlorpromazine-induced skin photosensitivity, chlorpromazine-sensitized photooxidation of squalene was studied in vitro. When squalene (in ethanolic solution or in an aqueous suspension) was irradiated with UV-A light in the presence of chlorpromazine, the yield of peroxidation products was greatly increased. Lines of evidence for the peroxidation were obtained by the iodometric determination and the thiobarbituric-acid method. Gas chromatography indicated that squalene was decomposed by the photosensitized reaction and the remaining amount was decreased exponentially with increasing fluence. The quenching effects of NaN3 and 2,5-dimethylfuran and the enhancing effect of D2O showed participation of singlet oxygen in the photosensitized reaction.
ISSN:0340-3696
1432-069X
DOI:10.1007/bf00412928