EFfect of interferon on vero cells persistently infected with SSPE virus and lytically infected with measles virus

The effect of lymphoblastoid interferon (IFN) on viral polypeptides synthesized in a Vero cell culture persistently infected with subacute sclerosing panencephalitis virus (SSPE-Vero) was compared to that of Vero cells infected with exogenous measles virus. After IFN treatment there was no significa...

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Bibliographic Details
Published in:Archives of virology 1986-01, Vol.90 (1-2), p.87-96
Main Authors: CRESPI, M, CHIU, M.-N, SCHOUB, B. D, LYONS, S. F
Format: Article
Language:English
Subjects:
2',5'-Oligoadenylate Synthetase - metabolism
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Cell Line
Cercopithecus aethiops
Enzyme Activation - drug effects
Fibroblasts - drug effects
Fibroblasts - microbiology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Interferon Type I - pharmacology
Kidney
measles virus
Measles virus - physiology
Miscellaneous
Protein Kinases - metabolism
Regulatory factors and their cellular receptors
Sindbis Virus - physiology
SSPE Virus - physiology
Viral Proteins - biosynthesis
Virus Replication - drug effects
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Summary:The effect of lymphoblastoid interferon (IFN) on viral polypeptides synthesized in a Vero cell culture persistently infected with subacute sclerosing panencephalitis virus (SSPE-Vero) was compared to that of Vero cells infected with exogenous measles virus. After IFN treatment there was no significant decrease in the synthesis of SSPE viral proteins, but inhibition of synthesis of measles polypeptides was readily seen. In Vero and SSPE-Vero cells IFN was able to inhibit replication of Sindbis virus although the effect in Vero cells was significantly more sensitive. In both cell lines IFN was able to stimulate 2'--5' oligoadenylate synthetase (E enzyme) but not the protein kinase system. The SSPE-Vero cells showed a lower basal level of E enzyme activity than the Vero cells.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01314147