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Anti-inflammatory and Immunosuppressive Effects of 1, 6-Anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221), a Novel Anhydro-enopyranose Derivative, on Experimental Animal Models
The anti-inflammatory effects of 1, 6-anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221) were investigated using animal models and compared with the effects of dexamethasone (DEX) and cyclosporin A (CYA). MT2221 inhibited carrageenan-induced acute inflammation and adjuvant arthritis in...
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| Published in: | Biological & pharmaceutical bulletin 1994/08/15, Vol.17(8), pp.1070-1074 |
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| Main Authors: | , , , , |
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| container_end_page | 1074 |
| container_issue | 8 |
| container_start_page | 1070 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 17 |
| creator | MIZUKOSHI, Sadanori TSUKAMOTO, Masamitsu TANAKA, Hisaki NAKAMURA, Kyoko KATO, Fuminori |
| description | The anti-inflammatory effects of 1, 6-anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221) were investigated using animal models and compared with the effects of dexamethasone (DEX) and cyclosporin A (CYA). MT2221 inhibited carrageenan-induced acute inflammation and adjuvant arthritis in rats, as well as the delayed-type hypersensitive response and collagen-induced arthritis (CIA) in mice. However, it seemed that this compound was more effective against murine CIA than upon the other inflammation models. The MT2221 mode of action differed from those of conventional non-steroidal anti-inflammatory drugs (NSAIDs) and disease modifying anti-rheumatic drugs (DMARDs). All of these drugs are effective against acute inflammation or adjuvant arthritis models, but not against murine CIA. DEX and CYA did inhibit murine CIA, but in other animal models, their mode of action differed from that of MT2221. Moreover, allograft transplantation in mice showed that MT2221 slightly prolonged the allograft survival time. These results suggest that MT2221 has not only anti-inflammatory but also im-munosuppressive effects based upon a novel mechanism of action that is different from NSAIDs, DMARDs, DEX and CYA. |
| doi_str_mv | 10.1248/bpb.17.1070 |
| format | article |
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MT2221 inhibited carrageenan-induced acute inflammation and adjuvant arthritis in rats, as well as the delayed-type hypersensitive response and collagen-induced arthritis (CIA) in mice. However, it seemed that this compound was more effective against murine CIA than upon the other inflammation models. The MT2221 mode of action differed from those of conventional non-steroidal anti-inflammatory drugs (NSAIDs) and disease modifying anti-rheumatic drugs (DMARDs). All of these drugs are effective against acute inflammation or adjuvant arthritis models, but not against murine CIA. DEX and CYA did inhibit murine CIA, but in other animal models, their mode of action differed from that of MT2221. Moreover, allograft transplantation in mice showed that MT2221 slightly prolonged the allograft survival time. These results suggest that MT2221 has not only anti-inflammatory but also im-munosuppressive effects based upon a novel mechanism of action that is different from NSAIDs, DMARDs, DEX and CYA.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.17.1070</identifier><identifier>PMID: 7820110</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>adjuvant arthritis ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; anti-inflammatory effect ; anti-rheumatic drug ; Arthritis, Experimental - prevention & control ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Carrageenan ; carrageenan-induced inflammation ; Collagen ; collagen-induced arthritis ; Cyclosporine - pharmacology ; Dexamethasone - pharmacology ; Edema - chemically induced ; Edema - prevention & control ; Female ; Furans - pharmacology ; Graft Rejection - drug therapy ; Hypersensitivity, Delayed - prevention & control ; immunosuppressive activity ; Immunosuppressive Agents - pharmacology ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Lew ; Rats, Sprague-Dawley</subject><ispartof>Biological and Pharmaceutical Bulletin, 1994/08/15, Vol.17(8), pp.1070-1074</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4930-9c009d3c1e815c34236689f03fa10eae42a0dc4a8683a2d1e9ee46c1a5ba3ef73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3401345$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7820110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIZUKOSHI, Sadanori</creatorcontrib><creatorcontrib>TSUKAMOTO, Masamitsu</creatorcontrib><creatorcontrib>TANAKA, Hisaki</creatorcontrib><creatorcontrib>NAKAMURA, Kyoko</creatorcontrib><creatorcontrib>KATO, Fuminori</creatorcontrib><title>Anti-inflammatory and Immunosuppressive Effects of 1, 6-Anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221), a Novel Anhydro-enopyranose Derivative, on Experimental Animal Models</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The anti-inflammatory effects of 1, 6-anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221) were investigated using animal models and compared with the effects of dexamethasone (DEX) and cyclosporin A (CYA). MT2221 inhibited carrageenan-induced acute inflammation and adjuvant arthritis in rats, as well as the delayed-type hypersensitive response and collagen-induced arthritis (CIA) in mice. However, it seemed that this compound was more effective against murine CIA than upon the other inflammation models. The MT2221 mode of action differed from those of conventional non-steroidal anti-inflammatory drugs (NSAIDs) and disease modifying anti-rheumatic drugs (DMARDs). All of these drugs are effective against acute inflammation or adjuvant arthritis models, but not against murine CIA. DEX and CYA did inhibit murine CIA, but in other animal models, their mode of action differed from that of MT2221. Moreover, allograft transplantation in mice showed that MT2221 slightly prolonged the allograft survival time. These results suggest that MT2221 has not only anti-inflammatory but also im-munosuppressive effects based upon a novel mechanism of action that is different from NSAIDs, DMARDs, DEX and CYA.</description><subject>adjuvant arthritis</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>anti-inflammatory effect</subject><subject>anti-rheumatic drug</subject><subject>Arthritis, Experimental - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Carrageenan</subject><subject>carrageenan-induced inflammation</subject><subject>Collagen</subject><subject>collagen-induced arthritis</subject><subject>Cyclosporine - pharmacology</subject><subject>Dexamethasone - pharmacology</subject><subject>Edema - chemically induced</subject><subject>Edema - prevention & control</subject><subject>Female</subject><subject>Furans - pharmacology</subject><subject>Graft Rejection - drug therapy</subject><subject>Hypersensitivity, Delayed - prevention & control</subject><subject>immunosuppressive activity</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Rats, Sprague-Dawley</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNpNkc2O0zAUhSMEGsrAijWSFwiBqIuvnd9lNS0w0gxshnV061zTjJI4YyfV5LV4Ap6AZ8JRS4Vk-Uo-n8658omi1yBWIOP8067frSBbgcjEk2gBKs54IiF5Gi1EATlPIcmfRy-8vxciIFJdRBdZLgWAWES_191Q87ozDbYtDtZNDLuKXbft2Fk_9r0j7-sDsa0xpAfPrGGwZClfd_upcparJYt5VVdkHycuuRldOFPD__ziGz7sHQWEU2f7yWFwJPb-9k5KCR-WDNk3e6CG_bP6n9qQqw84hOQlsx3bPvbhoaVuwJmv2zBubUWNfxk9M9h4enWal9GPz9u7q6_85vuX66v1DddxoQQvtBBFpTRQDolWsVRpmhdGKIMgCCmWKCodY57mCmUFVBDFqQZMdqjIZOoyenf07Z19GMkPZVt7TU2DHdnRl1laxInMIYAfj6B21ntHpuzD5uimEkQ591WGvkrIyrmvQL852Y67lqozeyoo6G9POnqNjQnfo2t_xlQsQt9JwDZH7N4P-JPOOrqh1g3NkVAUao7NT1dIP8t6j66kTv0F1tO3Jw</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>MIZUKOSHI, Sadanori</creator><creator>TSUKAMOTO, Masamitsu</creator><creator>TANAKA, Hisaki</creator><creator>NAKAMURA, Kyoko</creator><creator>KATO, Fuminori</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Anti-inflammatory and Immunosuppressive Effects of 1, 6-Anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221), a Novel Anhydro-enopyranose Derivative, on Experimental Animal Models</title><author>MIZUKOSHI, Sadanori ; TSUKAMOTO, Masamitsu ; TANAKA, Hisaki ; NAKAMURA, Kyoko ; KATO, Fuminori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4930-9c009d3c1e815c34236689f03fa10eae42a0dc4a8683a2d1e9ee46c1a5ba3ef73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>adjuvant arthritis</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>anti-inflammatory effect</topic><topic>anti-rheumatic drug</topic><topic>Arthritis, Experimental - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Carrageenan</topic><topic>carrageenan-induced inflammation</topic><topic>Collagen</topic><topic>collagen-induced arthritis</topic><topic>Cyclosporine - pharmacology</topic><topic>Dexamethasone - pharmacology</topic><topic>Edema - chemically induced</topic><topic>Edema - prevention & control</topic><topic>Female</topic><topic>Furans - pharmacology</topic><topic>Graft Rejection - drug therapy</topic><topic>Hypersensitivity, Delayed - prevention & control</topic><topic>immunosuppressive activity</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MIZUKOSHI, Sadanori</creatorcontrib><creatorcontrib>TSUKAMOTO, Masamitsu</creatorcontrib><creatorcontrib>TANAKA, Hisaki</creatorcontrib><creatorcontrib>NAKAMURA, Kyoko</creatorcontrib><creatorcontrib>KATO, Fuminori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIZUKOSHI, Sadanori</au><au>TSUKAMOTO, Masamitsu</au><au>TANAKA, Hisaki</au><au>NAKAMURA, Kyoko</au><au>KATO, Fuminori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and Immunosuppressive Effects of 1, 6-Anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221), a Novel Anhydro-enopyranose Derivative, on Experimental Animal Models</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1994</date><risdate>1994</risdate><volume>17</volume><issue>8</issue><spage>1070</spage><epage>1074</epage><pages>1070-1074</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The anti-inflammatory effects of 1, 6-anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221) were investigated using animal models and compared with the effects of dexamethasone (DEX) and cyclosporin A (CYA). MT2221 inhibited carrageenan-induced acute inflammation and adjuvant arthritis in rats, as well as the delayed-type hypersensitive response and collagen-induced arthritis (CIA) in mice. However, it seemed that this compound was more effective against murine CIA than upon the other inflammation models. The MT2221 mode of action differed from those of conventional non-steroidal anti-inflammatory drugs (NSAIDs) and disease modifying anti-rheumatic drugs (DMARDs). All of these drugs are effective against acute inflammation or adjuvant arthritis models, but not against murine CIA. DEX and CYA did inhibit murine CIA, but in other animal models, their mode of action differed from that of MT2221. Moreover, allograft transplantation in mice showed that MT2221 slightly prolonged the allograft survival time. These results suggest that MT2221 has not only anti-inflammatory but also im-munosuppressive effects based upon a novel mechanism of action that is different from NSAIDs, DMARDs, DEX and CYA.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>7820110</pmid><doi>10.1248/bpb.17.1070</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1994/08/15, Vol.17(8), pp.1070-1074 |
| issn | 0918-6158 1347-5215 |
| language | eng |
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| source | Free Full-Text Journals in Chemistry |
| subjects | adjuvant arthritis Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology anti-inflammatory effect anti-rheumatic drug Arthritis, Experimental - prevention & control Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Carrageenan carrageenan-induced inflammation Collagen collagen-induced arthritis Cyclosporine - pharmacology Dexamethasone - pharmacology Edema - chemically induced Edema - prevention & control Female Furans - pharmacology Graft Rejection - drug therapy Hypersensitivity, Delayed - prevention & control immunosuppressive activity Immunosuppressive Agents - pharmacology Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Pharmacology. Drug treatments Rats Rats, Inbred Lew Rats, Sprague-Dawley |
| title | Anti-inflammatory and Immunosuppressive Effects of 1, 6-Anhydro-3, 4-dideoxy-2-furfuryl-β-D-threo-3-enopyranose (MT2221), a Novel Anhydro-enopyranose Derivative, on Experimental Animal Models |
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