Elimination Studies of Antipyrine and its Metabolites in Healthy Saudi Arabians

• Published in: Human & experimental toxicology 1994-10, Vol.13 (10), p.658-662
• Main Authors: Ali, Hatim A., El-Yazigi, Adnan, Sieck, Jens O., Døssing, Martin, Saour, Jalal, Raines, Dale A., Ernst, Peter
• Format: Article
• Language: English
• Subjects: Administration, Oral; Adolescent; Adult; African Continental Ancestry Group; Antipyrine - administration & dosage; Antipyrine - analogs & derivatives; Antipyrine - pharmacokinetics; Antipyrine - urine; Asian Continental Ancestry Group; Chromatography, High Pressure Liquid; European Continental Ancestry Group; Female; Humans; Male; Metabolic Clearance Rate; Saudi Arabia
• ISSN: 0960-3271; 0144-5952; 1477-0903
• DOI: 10.1177/096032719401301002

1 We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydroxyantipyrine (4-OH AP), norantipyrine (NOR AP) and 3 hydroxymethylantipyrine (3-OHM AP) in 21 subjects. 2 The mean ± SD of the antipyrine clearance was 2.4 ± 1.1 h-1 (range 1.0-5.5 l h-1) and the corresponding value per kg body weight was 0.6 ± 0.2 ml min-1 kg-1. Urinary excretion of antipyrine (AP), 4-OH AP, NOR AP and 3-OHM AP expressed as a percentage of the oral dose of antipyrine given was 2.8 ± 2.2, 14.5 ± 6.9, 12.3 ± 5.6 and 7.6 ± 3.2 respectively. 3 Compared to Africans, Saudis preferentially metabolize AP to NOR AP and compared to Caucasians to 3-OHM AP, rather than to 4-OH AP. These discrepancies may reflect age differences between the study populations rather than genetic or ethnic variations.