In Vitro Killing of Spores and Hyphae of Aspergillus fumigatus and Rhizopus oryzae by Rabbit Neutrophil Cationic Peptides and Bronchoalveolar Macrophages

The fungicidal activity of six rabbit neutrophil cationic peptides (NP) against resting (dormant) spores, preincubated (swollen) spores, and hyphae of Aspergillus fumigatus and Rhizopus oryzae was examined. Whereas resting spores of both fungi were totally resistant to killing by up to 500 μg of NP/...

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Bibliographic Details
Published in:The Journal of infectious diseases 1986-09, Vol.154 (3), p.483-489
Main Authors: Levitz, Stuart M., Selsted, Michael E., Ganz, Tomas, Lehrer, Robert I., Diamond, Richard D.
Format: Article
Language:English
Subjects:
Animals
Antimicrobial Cationic Peptides
Aspergillus fumigatus
Aspergillus fumigatus - drug effects
Biological and medical sciences
Blood Proteins - pharmacology
Bronchi - cytology
Cell walls
Chitin
Conidia
Fundamental and applied biological sciences. Psychology
Fungal spores
Fungi
Hyphae
In Vitro Techniques
Macrophages
Macrophages - physiology
Male
Microbiology
Mycology
Neutrophils
Neutrophils - physiology
Original Articles
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Peptides - pharmacology
Phagocytosis - drug effects
Pulmonary Alveoli - cytology
Rabbits
Rhizopus - drug effects
Spores
Spores - drug effects
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Summary:The fungicidal activity of six rabbit neutrophil cationic peptides (NP) against resting (dormant) spores, preincubated (swollen) spores, and hyphae of Aspergillus fumigatus and Rhizopus oryzae was examined. Whereas resting spores of both fungi were totally resistant to killing by up to 500 μg of NP/ml, preincubated spores and hyphae were sensitive, under optimal conditions, to
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/154.3.483