Deceleration time in ischemic cardiomyopathy : Relation to echocardiographic and scintigraphic indices of myocardial viability and functional recovery after revascularization

In patients with heart failure secondary to left ventricular (LV) systolic dysfunction, a short deceleration time (DT) successfully predicts clinical outcome. The impact of myocardial viability and revascularization on the mitral inflow velocities, however, is unknown. Forty patients with ischemic c...

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Published in:Circulation (New York, N.Y.) N.Y.), 2001-03, Vol.103 (9), p.1232-1237
Main Authors: YONGQI YONG, NAGUEH, Sherif F, ZOGHBI, William A, SHIMONI, Sarah, SHAN, Kesavan, HE, Zuo-Xiang, REARDON, Michael J, LETSOU, George V, HOWELL, Jimmy F, VERANI, Mario S, QUINONES, Miguel A
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Blood Flow Velocity
Cardiology. Vascular system
Cardiomyopathies - complications
Cardiomyopathies - physiopathology
Cardiomyopathies - therapy
Coronary Artery Bypass
Coronary heart disease
Echocardiography, Doppler
Heart
Humans
Medical sciences
Mitral Valve - physiology
Myocardial Revascularization
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function
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Summary:In patients with heart failure secondary to left ventricular (LV) systolic dysfunction, a short deceleration time (DT) successfully predicts clinical outcome. The impact of myocardial viability and revascularization on the mitral inflow velocities, however, is unknown. Forty patients with ischemic cardiomyopathy underwent (201)Tl scintigraphy (SPECT) and 2D, Doppler, and dobutamine echocardiography (DE, to 40 microg. kg(-1). min(-1)) 2 days before CABG. Echocardiography was repeated 3 months after revascularization to determine recovery of function. Significant correlations were present between DT and LV contractile reserve by DE (r=0.72), scar perfusion defect by SPECT (r=-0.69), and the change in ejection fraction (DeltaEF) after surgery (r=0.77) (all P:150 ms effectively identified (sensitivity 79%, specificity 81%) patients with DeltaEF >/=5%. The population was divided into 2 groups according to DT: group 1 (DT >150 ms, n=21) and group 2 (DT
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.103.9.1232