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Deceleration time in ischemic cardiomyopathy : Relation to echocardiographic and scintigraphic indices of myocardial viability and functional recovery after revascularization
In patients with heart failure secondary to left ventricular (LV) systolic dysfunction, a short deceleration time (DT) successfully predicts clinical outcome. The impact of myocardial viability and revascularization on the mitral inflow velocities, however, is unknown. Forty patients with ischemic c...
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| Published in: | Circulation (New York, N.Y.) N.Y.), 2001-03, Vol.103 (9), p.1232-1237 |
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| container_end_page | 1237 |
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| container_title | Circulation (New York, N.Y.) |
| container_volume | 103 |
| creator | YONGQI YONG NAGUEH, Sherif F ZOGHBI, William A SHIMONI, Sarah SHAN, Kesavan HE, Zuo-Xiang REARDON, Michael J LETSOU, George V HOWELL, Jimmy F VERANI, Mario S QUINONES, Miguel A |
| description | In patients with heart failure secondary to left ventricular (LV) systolic dysfunction, a short deceleration time (DT) successfully predicts clinical outcome. The impact of myocardial viability and revascularization on the mitral inflow velocities, however, is unknown.
Forty patients with ischemic cardiomyopathy underwent (201)Tl scintigraphy (SPECT) and 2D, Doppler, and dobutamine echocardiography (DE, to 40 microg. kg(-1). min(-1)) 2 days before CABG. Echocardiography was repeated 3 months after revascularization to determine recovery of function. Significant correlations were present between DT and LV contractile reserve by DE (r=0.72), scar perfusion defect by SPECT (r=-0.69), and the change in ejection fraction (DeltaEF) after surgery (r=0.77) (all P:150 ms effectively identified (sensitivity 79%, specificity 81%) patients with DeltaEF >/=5%. The population was divided into 2 groups according to DT: group 1 (DT >150 ms, n=21) and group 2 (DT |
| doi_str_mv | 10.1161/01.CIR.103.9.1232 |
| format | article |
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Forty patients with ischemic cardiomyopathy underwent (201)Tl scintigraphy (SPECT) and 2D, Doppler, and dobutamine echocardiography (DE, to 40 microg. kg(-1). min(-1)) 2 days before CABG. Echocardiography was repeated 3 months after revascularization to determine recovery of function. Significant correlations were present between DT and LV contractile reserve by DE (r=0.72), scar perfusion defect by SPECT (r=-0.69), and the change in ejection fraction (DeltaEF) after surgery (r=0.77) (all P:<0.01). DT >150 ms effectively identified (sensitivity 79%, specificity 81%) patients with DeltaEF >/=5%. The population was divided into 2 groups according to DT: group 1 (DT >150 ms, n=21) and group 2 (DT </=150 ms, n=19). At baseline, NYHA class, LV EF, age, and use of cardiovascular drugs were similar between the 2 groups. The number of viable segments by both DE and SPECT, however, was higher in group 1 (both P:<0.01), and only patients in group 1 had an increase in EF (29+/-4.8% to 40+/-8%, P:<0.01) after surgery. Death and heart transplantation occurred in 7 patients from group 2 and 1 patient from group 1 (P:=0.017).
In patients with ischemic cardiomyopathy, the reduced amount of viable myocardium results in a restrictive mitral inflow pattern, which in turn predicts poor survival.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.103.9.1232</identifier><identifier>PMID: 11238266</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Analysis of Variance ; Biological and medical sciences ; Blood Flow Velocity ; Cardiology. Vascular system ; Cardiomyopathies - complications ; Cardiomyopathies - physiopathology ; Cardiomyopathies - therapy ; Coronary Artery Bypass ; Coronary heart disease ; Echocardiography, Doppler ; Heart ; Humans ; Medical sciences ; Mitral Valve - physiology ; Myocardial Revascularization ; Tomography, Emission-Computed, Single-Photon ; Treatment Outcome ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function</subject><ispartof>Circulation (New York, N.Y.), 2001-03, Vol.103 (9), p.1232-1237</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c319t-f11597957ab34bb8e16686cd5f0b3d7c4e00429995e987c1eaf560450674c9b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=914872$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11238266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YONGQI YONG</creatorcontrib><creatorcontrib>NAGUEH, Sherif F</creatorcontrib><creatorcontrib>ZOGHBI, William A</creatorcontrib><creatorcontrib>SHIMONI, Sarah</creatorcontrib><creatorcontrib>SHAN, Kesavan</creatorcontrib><creatorcontrib>HE, Zuo-Xiang</creatorcontrib><creatorcontrib>REARDON, Michael J</creatorcontrib><creatorcontrib>LETSOU, George V</creatorcontrib><creatorcontrib>HOWELL, Jimmy F</creatorcontrib><creatorcontrib>VERANI, Mario S</creatorcontrib><creatorcontrib>QUINONES, Miguel A</creatorcontrib><title>Deceleration time in ischemic cardiomyopathy : Relation to echocardiographic and scintigraphic indices of myocardial viability and functional recovery after revascularization</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>In patients with heart failure secondary to left ventricular (LV) systolic dysfunction, a short deceleration time (DT) successfully predicts clinical outcome. The impact of myocardial viability and revascularization on the mitral inflow velocities, however, is unknown.
Forty patients with ischemic cardiomyopathy underwent (201)Tl scintigraphy (SPECT) and 2D, Doppler, and dobutamine echocardiography (DE, to 40 microg. kg(-1). min(-1)) 2 days before CABG. Echocardiography was repeated 3 months after revascularization to determine recovery of function. Significant correlations were present between DT and LV contractile reserve by DE (r=0.72), scar perfusion defect by SPECT (r=-0.69), and the change in ejection fraction (DeltaEF) after surgery (r=0.77) (all P:<0.01). DT >150 ms effectively identified (sensitivity 79%, specificity 81%) patients with DeltaEF >/=5%. The population was divided into 2 groups according to DT: group 1 (DT >150 ms, n=21) and group 2 (DT </=150 ms, n=19). At baseline, NYHA class, LV EF, age, and use of cardiovascular drugs were similar between the 2 groups. The number of viable segments by both DE and SPECT, however, was higher in group 1 (both P:<0.01), and only patients in group 1 had an increase in EF (29+/-4.8% to 40+/-8%, P:<0.01) after surgery. Death and heart transplantation occurred in 7 patients from group 2 and 1 patient from group 1 (P:=0.017).
In patients with ischemic cardiomyopathy, the reduced amount of viable myocardium results in a restrictive mitral inflow pattern, which in turn predicts poor survival.</description><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathies - complications</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Cardiomyopathies - therapy</subject><subject>Coronary Artery Bypass</subject><subject>Coronary heart disease</subject><subject>Echocardiography, Doppler</subject><subject>Heart</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mitral Valve - physiology</subject><subject>Myocardial Revascularization</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpFkVGL1DAUhYMo7rj6A3yRgOBba27TpI1vMqvrwoKw6HNJ0xsnkjZj0g6MP8rfaGamq0_h3HznXJJDyGtgJYCE9wzK7d1DCYyXqoSKV0_IBkRVF7Xg6inZMMZU0fCquiIvUvqZpeSNeE6uIMNtJeWG_LlBgx6jnl2Y6OxGpG6iLpkdjs5Qo-PgwngMez3vjvQDfUC_ooGi2YUL8CPq_S7jehpoMm6a3ePETYMzmGiwNKecae3pweneeTcfzw67TOaUmS8imnDAmOd2xpjlQSezeB3d7_Pal-SZ1T7hq_W8Jt8_f_q2_VLcf7292368LwwHNRcWQKhGiUb3vO77FkHKVppBWNbzoTE1MlZXSimBqm0MoLZCslow2dRG9Zxfk3eX3H0MvxZMczfmP0Hv9YRhSV0jlag5QAbhApoYUopou310o47HDlh3Kqlj0OWSsuSd6k4lZc-bNXzpRxz-O9ZWMvB2BfLrtbdRT8alf5yCum0q_he_ep54</recordid><startdate>20010306</startdate><enddate>20010306</enddate><creator>YONGQI YONG</creator><creator>NAGUEH, Sherif F</creator><creator>ZOGHBI, William A</creator><creator>SHIMONI, Sarah</creator><creator>SHAN, Kesavan</creator><creator>HE, Zuo-Xiang</creator><creator>REARDON, Michael J</creator><creator>LETSOU, George V</creator><creator>HOWELL, Jimmy F</creator><creator>VERANI, Mario S</creator><creator>QUINONES, Miguel A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010306</creationdate><title>Deceleration time in ischemic cardiomyopathy : Relation to echocardiographic and scintigraphic indices of myocardial viability and functional recovery after revascularization</title><author>YONGQI YONG ; NAGUEH, Sherif F ; ZOGHBI, William A ; SHIMONI, Sarah ; SHAN, Kesavan ; HE, Zuo-Xiang ; REARDON, Michael J ; LETSOU, George V ; HOWELL, Jimmy F ; VERANI, Mario S ; QUINONES, Miguel A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-f11597957ab34bb8e16686cd5f0b3d7c4e00429995e987c1eaf560450674c9b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathies - complications</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Cardiomyopathies - therapy</topic><topic>Coronary Artery Bypass</topic><topic>Coronary heart disease</topic><topic>Echocardiography, Doppler</topic><topic>Heart</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mitral Valve - physiology</topic><topic>Myocardial Revascularization</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Treatment Outcome</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YONGQI YONG</creatorcontrib><creatorcontrib>NAGUEH, Sherif F</creatorcontrib><creatorcontrib>ZOGHBI, William A</creatorcontrib><creatorcontrib>SHIMONI, Sarah</creatorcontrib><creatorcontrib>SHAN, Kesavan</creatorcontrib><creatorcontrib>HE, Zuo-Xiang</creatorcontrib><creatorcontrib>REARDON, Michael J</creatorcontrib><creatorcontrib>LETSOU, George V</creatorcontrib><creatorcontrib>HOWELL, Jimmy F</creatorcontrib><creatorcontrib>VERANI, Mario S</creatorcontrib><creatorcontrib>QUINONES, Miguel A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YONGQI YONG</au><au>NAGUEH, Sherif F</au><au>ZOGHBI, William A</au><au>SHIMONI, Sarah</au><au>SHAN, Kesavan</au><au>HE, Zuo-Xiang</au><au>REARDON, Michael J</au><au>LETSOU, George V</au><au>HOWELL, Jimmy F</au><au>VERANI, Mario S</au><au>QUINONES, Miguel A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deceleration time in ischemic cardiomyopathy : Relation to echocardiographic and scintigraphic indices of myocardial viability and functional recovery after revascularization</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2001-03-06</date><risdate>2001</risdate><volume>103</volume><issue>9</issue><spage>1232</spage><epage>1237</epage><pages>1232-1237</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>In patients with heart failure secondary to left ventricular (LV) systolic dysfunction, a short deceleration time (DT) successfully predicts clinical outcome. The impact of myocardial viability and revascularization on the mitral inflow velocities, however, is unknown.
Forty patients with ischemic cardiomyopathy underwent (201)Tl scintigraphy (SPECT) and 2D, Doppler, and dobutamine echocardiography (DE, to 40 microg. kg(-1). min(-1)) 2 days before CABG. Echocardiography was repeated 3 months after revascularization to determine recovery of function. Significant correlations were present between DT and LV contractile reserve by DE (r=0.72), scar perfusion defect by SPECT (r=-0.69), and the change in ejection fraction (DeltaEF) after surgery (r=0.77) (all P:<0.01). DT >150 ms effectively identified (sensitivity 79%, specificity 81%) patients with DeltaEF >/=5%. The population was divided into 2 groups according to DT: group 1 (DT >150 ms, n=21) and group 2 (DT </=150 ms, n=19). At baseline, NYHA class, LV EF, age, and use of cardiovascular drugs were similar between the 2 groups. The number of viable segments by both DE and SPECT, however, was higher in group 1 (both P:<0.01), and only patients in group 1 had an increase in EF (29+/-4.8% to 40+/-8%, P:<0.01) after surgery. Death and heart transplantation occurred in 7 patients from group 2 and 1 patient from group 1 (P:=0.017).
In patients with ischemic cardiomyopathy, the reduced amount of viable myocardium results in a restrictive mitral inflow pattern, which in turn predicts poor survival.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11238266</pmid><doi>10.1161/01.CIR.103.9.1232</doi><tpages>6</tpages></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 2001-03, Vol.103 (9), p.1232-1237 |
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| source | EZB Electronic Journals Library |
| subjects | Analysis of Variance Biological and medical sciences Blood Flow Velocity Cardiology. Vascular system Cardiomyopathies - complications Cardiomyopathies - physiopathology Cardiomyopathies - therapy Coronary Artery Bypass Coronary heart disease Echocardiography, Doppler Heart Humans Medical sciences Mitral Valve - physiology Myocardial Revascularization Tomography, Emission-Computed, Single-Photon Treatment Outcome Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Function |
| title | Deceleration time in ischemic cardiomyopathy : Relation to echocardiographic and scintigraphic indices of myocardial viability and functional recovery after revascularization |
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