Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis

Thyroid function and serum TSI levels in two siblings with neonatal thyrotoxicosis are described. The first infant was treated with exchange transfusion and potassium iodide. The second infant was treated with intrauterine propylthiouracil followed by potassium iodide. In contrast to the first infan...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pediatrics 1986-04, Vol.145 (1-2), p.143-147
Main Authors: WIT, J. M, REES-SMITH, B, CREAGH, F. M, BRUINSE, H. W, VAN DER HEIDE, D, DOCTER, R, GERARDS, L. J
Format: Article
Language:English
Subjects:
Adult
Antibodies - analysis
Biological and medical sciences
Endocrinopathies
Exchange Transfusion, Whole Blood
Female
Follow-Up Studies
Half-Life
Humans
Hyperthyroidism - congenital
Hyperthyroidism - genetics
Hyperthyroidism - therapy
Immunoglobulin G - analysis
Immunoglobulins, Thyroid-Stimulating
Infant
Infant, Newborn
Male
Malignant tumors
Medical sciences
Potassium Iodide - therapeutic use
Pregnancy
Propylthiouracil - therapeutic use
Receptors, Cell Surface - immunology
Receptors, Thyrotropin
Thyroid Function Tests
Thyroid Gland - immunology
Thyroid. Thyroid axis (diseases)
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thyroid function and serum TSI levels in two siblings with neonatal thyrotoxicosis are described. The first infant was treated with exchange transfusion and potassium iodide. The second infant was treated with intrauterine propylthiouracil followed by potassium iodide. In contrast to the first infant, the second infant had no clinical sign of neonatal thyrotoxicosis. He also had lower TSI levels with a biological half-life of 5 days. Only one of three assays showed some TSI activity in breast milk.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF00441879