Molecular Epidemiology of Neonatal Meningitis Due to Citrobacter diversus: A Study of Isolates from Hospitals in Maryland

Six cases of neonatal meningitis due to Citrobacter diversus were diagnosed in three Baltimore (Maryland) hospitals between 1983 and 1985. Using plasmid profiles, biotypes, serotypes, and chromosomal restriction endonuclease digests as epidemiological markers, we studied 63 isolates of C. diversus (...

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Bibliographic Details
Published in:The Journal of infectious diseases 1986-09, Vol.154 (3), p.409-414
Main Authors: Morris, J. Glenn, Feng-Ying, C. Lin, Morrison, Charlotte B., Gross, R. J., Khabbaz, Rima, O'D. Maher, Kevin, Rowe, Bernard, Israel, Ebenezer, Libonati, Joseph P.
Format: Article
Language:English
Subjects:
Applied sciences
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Bacterial meningitis
Biological and medical sciences
Cerebrospinal fluid
Citrobacter - classification
Citrobacter - genetics
Citrobacter - isolation & purification
Citrobacter - metabolism
Citrobacter koseri
Cross Infection - microbiology
Cultural diversity
DNA, Bacterial - isolation & purification
Exact sciences and technology
Human bacterial diseases
Humans
Infant, Newborn
Infants
Infectious diseases
Maryland
Medical schools
Medical sciences
Meningitis
Meningitis - microbiology
Nurseries, Hospital
Nurses
Original Articles
Other techniques and industries
Plasmids
Serotyping
Urine
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Summary:Six cases of neonatal meningitis due to Citrobacter diversus were diagnosed in three Baltimore (Maryland) hospitals between 1983 and 1985. Using plasmid profiles, biotypes, serotypes, and chromosomal restriction endonuclease digests as epidemiological markers, we studied 63 isolates of C. diversus (including four isolates from cerebrospinal fluid) from these and seven other hospitals in Maryland. Within two of the three hospitals with meningitis cases, the same strain of C. diversus was isolated from case infant(s), healthy neonates, and nursery personnel. In all three hospitals, C. diversus strains different from those implicated as a cause of meningitis were also isolated. Other than the meningitisassociated strains, 15 different strains of C. diversus were isolated from infants in the hospitals studied, with several distinct clusters of asymptomatic, colonized infants identified.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/154.3.409