The Role of Parvovirus B19 in Aplastic Crisis and Erythema Infectiosum (Fifth Disease)

• Published in: The Journal of infectious diseases 1986-09, Vol.154 (3), p.383-393
• Main Authors: Chorba, Terence, Coccia, Peter, Holman, Robert C., Tattersall, Peter, Anderson, Larry J., Sudman, Jon, Young, Neal S., Kurczynski, Elizabeth, Saarinen, Ulla M., Moir, Robyn, Lawrence, Dale N., Jason, Janine M., Evatt, Bruce
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anemia, Aplastic - epidemiology; Anemia, Aplastic - etiology; Anemia, Hemolytic - complications; Anemia, Sickle Cell - complications; Antibodies, Viral - immunology; Biological and medical sciences; Child; Child, Preschool; Disease Outbreaks; DNA, Viral - metabolism; Epidemiology; Erythema - epidemiology; Erythema - etiology; Erythema infectiosum; Exanthema; Female; Hemoglobin SC disease; Hemolytic anemia; Human viral diseases; Humans; Immunoglobulin M - immunology; Infections; Infectious diseases; Male; Medical sciences; Ohio; Original Articles; Parvoviridae - immunology; Parvoviridae Infections - complications; Parvoviridae Infections - epidemiology; Parvoviridae Infections - transmission; Parvovirus; Sickle cell disease; Urine; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viruses
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/154.3.383

In 1984, simultaneous outbreaks of aplastic crisis and erythema infectiosum occurred in northeastern Ohio. Sera were analyzed from 26 patients with aplastic crisis: 24 had IgM specific for parvovirus B19, five had Bl9-like particles by electron microscopy, and 13 had DNA from B19; no sera from 33 controls had evidence of recent infection with B19 (P < .0001). DNA from B19was also detected in specimens of throat gargle and urine from two patients with aplastic crisis. Sera from 36 of 51 children with erythema infectiosum had Bl9-specific IgM, compared with serum from one of 42 susceptible controls (P < .0001). DNA from B19 was detected in sera from only two of 51 patients who had erythema infectiosum. The secondary attack rates among susceptible contacts decreased with age (overall total, 49.6%). Differential rates of asymptomatic infection were observed among black (68.8%) and white (20.0%) household members (P = .003). These were the first identified simultaneous outbreaks of aplastic crisis and erythema infectiosum. Their occurrence provided an opportunity to study the epidemiology and spectrum of B19infection with geographically and temporally matched comparison groups; our results support the hypothesis that infection with parvovirus causes these two clinical entities.