Antibiotic susceptibilities among recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis from fifteen countries

Between July 1998 and July 1999, 3,060 Haemophilus influenzae and 1,486 Moraxella catarrhalis strains were isolated in 31 centers in 15 countries in order to determine their antimicrobial susceptibilities and the presence of beta-lactamase production in Haemophilus influenzae. Overall 17.1% of the H...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2001-01, Vol.20 (1), p.55-60
Main Authors: BANDAK, S. I, TURNAK, M. R, ALLEN, B. S, BOLZON, L. D, PRESTON, D. A, BOUCHILLON, S. K, HOBAN, D. J
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial agents
beta-Lactamases - biosynthesis
Biological and medical sciences
cefprozil
Drug Resistance, Bacterial
Drug Resistance, Multiple, Bacterial
Global Health
Haemophilus influenzae
Haemophilus influenzae - drug effects
Haemophilus influenzae - enzymology
Infections
Laboratories
Medical sciences
Microbial Sensitivity Tests
Moraxella (Branhamella) catarrhalis - drug effects
Moraxella catarrhalis
Pharmacology. Drug treatments
Prospective Studies
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Summary:Between July 1998 and July 1999, 3,060 Haemophilus influenzae and 1,486 Moraxella catarrhalis strains were isolated in 31 centers in 15 countries in order to determine their antimicrobial susceptibilities and the presence of beta-lactamase production in Haemophilus influenzae. Overall 17.1% of the Haemophilus influenzae isolates were beta-lactamase positive, while more than 95% were susceptible to amoxicillin/clavulanate, cefaclor, loracarbef, cefuroxime, azithromycin and ciprofloxacin. Eleven (0.3%) isolates were beta-lactamase positive and ampicillin resistant and 7 (0.2%) isolates were ciprofloxacin resistant. The minimum inhibitory concentrations for 90% of the isolates tested were lowest for ciprofloxacin (0.03) and highest for cefprozil (8) against Moraxella catarrhalis.
ISSN:0934-9723
1435-4373
DOI:10.1007/PL00011235