Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section

A prospective, randomized study was performed in order to evaluate the effect of cefotiam in the prevention of postoperative infectious morbidity in patients undergoing low-risk elective cesarean section. A total of 146 patients were randomly assigned to receive either intraoperative single-shot pro...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2001, Vol.20 (1), p.40-42
Main Authors: KOLBEN, M, MANDOKI, E, ULM, K, FREITAG, K
Format: Article
Language:English
Subjects:
Adult
Antibacterial agents
Antibiotic Prophylaxis
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Infections - epidemiology
Bacterial Infections - etiology
Bacterial Infections - prevention & control
Biological and medical sciences
Cefotiam - therapeutic use
Cephalosporins - therapeutic use
Cesarean Section
Elective Surgical Procedures
Female
Humans
Medical sciences
Middle Aged
Morbidity
Pharmacology. Drug treatments
Postoperative Complications - drug therapy
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Prevention
Prophylaxis
Prospective Studies
Risk Factors
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Summary:A prospective, randomized study was performed in order to evaluate the effect of cefotiam in the prevention of postoperative infectious morbidity in patients undergoing low-risk elective cesarean section. A total of 146 patients were randomly assigned to receive either intraoperative single-shot prophylaxis with 2 g cefotiam (study group, n =76) or no prophylaxis (control group, n=70). Due to a higher rate of urinary tract infections, the incidence of infectious morbidity after cefotiam prophylaxis was higher in the study group than in the control group (16% vs. 9%, P=0.1). Postoperative infectious morbidity following low-risk elective cesarean section cannot be reduced by intraoperative cefotiam prophylaxis.
ISSN:0934-9723
1435-4373
DOI:10.1007/s100960000365